Abstract：Objective: To explore the predictive value of soluble lectin-like oxidized low-density lipoprotein receptor-1 (sLOX-1), hypoxia-inducible factor-1α (HIF-1α), and insulin-like growth factor-1 (IGF-1) on delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH). Methods: A total of 104 patients with aSAH in the hospital from March 2019 to March 2022 were selected as the research subjects. According to the occurrence of DCI, the patients were divided into a DCI group and a non-DCI group. The general clinical data [triacylglycerol (TG), intracranial pressure (ICP), Hunt-Hess grading] and serum sLOX-1, HIF-1α, and IGF-1 levels were compared between the two groups. Pearson correlation analysis was used to analyze the correlation between serum sLOX-1, HIF-1α, IGF-1 and TG, ICP, and Hunt-Hess grading. The receiver operating characteristic (ROC) curve was drawn to assess the predictive efficiency of serum sLOX-1, HIF-1α, and IGF-1 on DCI after aSAH. Results: The TG, ICP and Hunt-Hess grading in the DCI group were higher than those in the non-DCI group (P<0.05). The levels of serum sLOX-1 and HIF-1α in the DCI group were higher than those in the non-DCI group (P<0.05) while the level of IGF-1 was lower than that in the non-DIC group (P<0.05). Pearson correlation analysis showed that serum sLOX-1 and HIF-1α levels were positively correlated with TG, ICP, and Hunt-Hess grading (P<0.05), but serum IGF-1 level was negatively correlated with TG, ICP, and Hunt-Hess grading (P<0.05). ROC curve showed that the sensitivities and specificities of serum sLOX-1, HIF-1α, IGF-1 alone and in combination on predicting DCI after aSAH were 87.10%/79.50%, 90.30%/83.60%, 83.90%/79.50%, and 96.80%/78.10% respectively, and the corresponding AUCs were 0.894, 0.920, 0.886, and 0.975 respectively. Conclusion: sLOX-1, HIF-1α, and IGF-1 are related to the occurrence of DCI after aSAH, and combined detection can predict DCI after aSAH to a certain extent.
2023, Vol. 29 
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