Effects of Combined Orthodontic Periodontal Treatment on the Expression of Periodontal Pathogens and Inflammatory Factors in Periodontitis Patients with Malocclusion
CHEN Gang, et al
Yichang Central People's Hospital, Hubei Yichang 443000, China
Abstract：Objective: To investigate the expression of periodontal pathogens and inflammatory factors in patients with periodontitis associated with malocclusion by orthodontic combined periodontal treatment. Methods: All the enrolled patients were 84 patients with malocclusion periodontitis who were admitted to our hospital from January 2017 to January 2021. According to random number table method, they were divided into control group (n=42, orthodontic treatment alone) and combined group (n=42, orthodontic periodontal treatment combined). The total effective rate was compared between the two groups. Compared the two groups before treatment, after treatment of periodontal related index [plaque index (PLI), periodontal pocket probing depth (PD), attachment level (AL), gingival bleeding index (SBI)], periodontal pathogens [gum porphyrin (Pg) bacterium, fossett steiner bacteria (Tf), teeth tartar treponema (Td), intermediate platts bacteria (Pi)], periodontal tissue inflammation Cytokines [tumor necrosis factor -α (TNF-α), interleukin-6 (IL-6), interleukin-10 (IL-10)] levels. Results: The total effective rate in combined group was 92.86%, which was higher than 76.19% in control group (P<0.05). Before treatment, there were no significant differences in periodontal related indicators, pathogenic bacteria and periodontitis factors in gingival crevicular fluid between 2 groups (P>0.05). After treatment, PLI, PD, SBI, AL, Pg, Tf, Td, Pi, TNF-α and IL-6 in both groups were decreased (P<0.05), while IL-10 was increased (P<0.05), and the difference between before and after treatment in combined group was greater than that in control group (P<0.05). Conclusion: Orthodontic periodontitis combined with malocclusion can improve the periodontal state of patients, reduce the level of pathogenic bacteria and reduce the inflammatory state.
陈刚, 莫丽飞, 张晓静. 正畸牙周联合治疗对伴错合畸形牙周炎患者牙周致病菌及牙周组织炎症因子表达的影响[J]. 河北医学, 2023, 29(1): 131-136.
CHEN Gang, et al. Effects of Combined Orthodontic Periodontal Treatment on the Expression of Periodontal Pathogens and Inflammatory Factors in Periodontitis Patients with Malocclusion. HeBei Med, 2023, 29(1): 131-136.
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2023, Vol. 29 
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