Abstract：Objective: To explore the predictive value of multiple inflammatory indices for cardiovascular complications in children with Kawasaki disease. Methods: A total of 127 children with KD admitted to our hospital from January 2020 to May 2022 were continuously collected as the research subjects, and they were divided into high MII group and low MII group according to the median of MII. Demographic data such as gender and age were collected using self-made general information questionnaire, and clinical data such as fever time, conjunctival hyperemia, and lymphadenopathy were obtained through electronic medical record system. Children were followed up for 12 months with cardiovascular complications as the outcome. Results: There was no significant difference in gender, fever time, and lymph node enlargement rate between the high MII group and the low MII group (P>0.05). The age and conjunctival hyperemia rate in the high MII group were higher than those in the low MII group, and the differences were statistically significant (P<0.05). The results of the K-M survival curve analysis showed that the median cardiovascular complication rates were 87.50% and 90.63% in the high MII-1 and high MII-2 groups, respectively, and 76.19% and 74.60% in the low MII-1 and low MII-2 groups, respectively, with statistically significant differences between the two groups (χ2=10.680, 10.860 , P=0.001, 0.001). Multivariate analysis showed that MII-1 (OR=2.247, P<0.001) and MII-2 (OR=2.134, P<0.001) were independent influencing factors of cardiovascular complications in children with KD. The results of ROC analysis showed that when the values of MII-1 and MII-2 were 784.64 and 21876.76, respectively, the maximum predictive performance of cardiovascular complications in children with KD after 12 months of follow-up was achieved, and the areas under the curve were 0.680 and 0.726, respectively. Conclusion: Multiple inflammatory indices have certain clinical value in predicting cardiovascular complications in children with Kawasaki disease, and are worthy of clinical application
李方旺, 胡方启, 吴露依, 王利华, 饶军. 多重炎症指数对川崎病患儿心血管并发症的预测价值[J]. 河北医学, 2023, 29(1): 103-107.
LI Fangwang, HU Fangqi, WU Luyi, et al. Predictive Value of Multiple Inflammatory Indices for Cardiovascular Complications in Children with Kawasaki Disease. HeBei Med, 2023, 29(1): 103-107.
[1] Qian B,Huang H,Cheng M,et al.Mechanism of HMGB1-RAGE in kawasaki disease with coronary artery injury[J].Eur Med Res,2020,25(1):8. [2] Qin J,Zheng Y,Ding Y,et al.Co-culture of peripheral blood mononuclear cell (PBMC) and human coronary artery endothelial cell (HCAEC) reveals the important role of autophagy implicated in Kawasaki disease[J].Transl Pediatr,2021,10(12):3140-3150. [3] 吴业媚,徐明国.外周血细胞参数对川崎病临床预测作用的研究进展[J].中华实用儿科临床杂志,2020,35(13):1027-1030. [4] 陈芃螈,杨超,李刚,等.系统性免疫-炎症指数对川崎病患儿冠脉扩张的预测价值[J].中国免疫学杂志,2020,36(16):2003-2006. [5] Gozdas HT,Kayis SA,Damarsoy T,et al.Multi-inflammatory index as a novel mortality predictor in critically Ill COVID-19 patients[J].Intensive Care Med,2022,37(11):1480-1485. [6] Wang L,Yang Y,Cui Q,et al.Evaluating the added predictive ability of MMP-9 in serum for Kawasaki disease with coronary artery lesions[J].Investig Med,2021,69(1):13-19. [7] Su Y,Feng S,Luo L,et al.Association between IL-35 and coronary arterial lesions in children with Kawasaki disease[J].Clin Exp Med,2019,19(1):87-92. [8] 杨燕飞,张丽萍.心率变异性指标和中性粒细胞与淋巴细胞比值对小儿川崎病并发冠状动脉病变的诊断价值[J].发育医学电子杂志,2022,10(3):174-181. [9] Zhang X,Ya-Wang Shao,Ya-Lan Zhang,et al.Serum Lp-PLA2 level predicting coronary artery lesions in children with kawasaki disease[J].Heart Surg Forum,2021,24(4):611-618. [10] Chang LS,Lin YJ,et al.Neutrophil-to-lymphocyte ratio and scoring system for predicting coronary artery lesions of Kawasaki disease[J].BMC Pediatr,2020,20(1):398. [11] An HS,Kim GB,Song MK,et al.The occurrence of coronary artery lesions in kawasaki disease based on C-reactive protein levels:a retrospective cohort study[J].Pediatr Rheumatol Online,2021,19(1):78.
2023, Vol. 29 
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