Abstract：Objective: To analyze the effects of maintenance hemodialysis (MHD) combined with hemoperfusion (HP) on toxin clearance and neuroendocrine hormones in patients with uremia and hypertension. Methods: A total of 92 uremic patients with hypertension who were admitted to our hospital from June 2018 to June 2020 were selected and divided into the control group (MHD group, n=46) and the observation group (HP+MHD group, n=46) by random table method. Clinical data of patients were collected to compare the changes in the levels of toxin level factors C-reactive protein (CRP), homocysteine (Hcy), macronutrient toxin (β2-MG), horse uric acid (HA), parathyroid hormone (PTH) levels, changes in the levels of neuroendocrine hormones angiotensin Ⅱ (Ang Ⅱ), renin (PRA), aldosterone (Ald), and the occurrence of adverse reactions in both groups before and after treatment. Results: After treatment, the levels of CRP, Hcy, β2-MG, HA and PTH in patients of the observation group decreased compared with those before treatment, while the levels of β2-MG in patients of the control group decreased, but the levels of CRP, Hcy, HA and PTH increased compared with those before treatment, and the levels of endotoxin in the observation group after treatment were compared with those in the control group (P<0. 05), the improvement effect of neuroendocrine hormones Ang Ⅱ, PRA and Ald in the observation group patients after treatment was significantly different compared with the control group (P<0. 05), and the adverse reactions in the observation group patients were significantly lower than those in the control group (P<0. 05). Conclusion: Maintenance hemodialysis combined with hemoperfusion in the treatment of uremic patients with hypertension can effectively remove toxins from the patient's body and reduce the secretion of neuroendocrine hormones, and the clinical effect is significant.
王婷, 李玉芳, 张丽, 王顺, 焦丽娟, 帕热旦木·托乎提. 维持性血液透析合并血液灌流对尿毒症合并高血压患者毒素清除作用及神经内分泌激素的影响[J]. 河北医学, 2022, 28(12): 2077-2080.
WANG Ting, LI Yufang, ZHANG Li, et al. Effects of Maintenance Hemodialysis Combined with Hemoperfusion on Toxin Clearance and Neuroendocrine Hormone in Uremic Patients with Hypertension. HeBei Med, 2022, 28(12): 2077-2080.
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2022, Vol. 28 
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