Abstract：Objective: To investigate the correlation between CT perfusion imaging findings before and after embolization in acute ischemic stroke and patients' disease recurrence and cognitive impairment. Methods: 97 patients with acute ischemic stroke treated in neurosurgery of our hospital from July 2019 to October 2021 were selected. All patients were treated with mechanical thrombectomy, and all patients were examined by 64 row spiral CT before and after thrombectomy. The cognitive function of patients with and without cognitive impairment was evaluated at discharge. The baseline data of patients with and without cognitive impairment and the levels of rCBF, rCBV and rmtt before and after thrombectomy were compared. All patients were followed up for at least 6 months to compare the baseline data of recurrent and non recurrent patients and the levels of rCBF, rCBV and rmtt before and after thrombectomy. The correlation between rCBF, rCBV, rmtt and recurrence and cognitive impairment was analyzed. Results: The rCBF and rCBV of 97 patients after thrombectomy were significantly higher than those before thrombectomy, while the rmtt was significantly lower. Among them, 28 patients had cognitive impairment and 19 patients had recurrence. The rCBF and rCBV of patients with cognitive impairment and normal cognitive function increased significantly after thrombectomy, and the rMTT of patients with normal cognitive function decreased significantly (P<0. 05). At the same time, the rCBF and rCBV of patients with normal cognitive function before and after thrombectomy were significantly higher than those of patients with cognitive impairment, and the rMTT was significantly lower than those of patients with cognitive impairment (P<0. 05); the rCBF and rCBV in the recurrent group and the non recurrent group were significantly higher and the rMTT was significantly lower after thrombectomy. At the same time, the rCBF and rCBV in the recurrent group were significantly higher than those in the non recurrent group, and the rMTT was significantly lower than that in the non recurrent group (P<0. 05). After multivariate logistic regression analysis, it was found that the low level of rCBF and rCBV before and after thrombectomy and the high level of rMTT before and after thrombectomy were risk factors affecting cognitive dysfunction of patients, while the low level of rCBF and rCBV after thrombectomy and the high level of rMTT after thrombectomy were risk factors affecting disease recurrence of patients, and the difference was statistically significant (P<0. 05). Conclusion: For patients with acute ischemic stroke, the levels of rCBF, rCBV and rMTT can be determined by CTP before and after thrombectomy, so as to provide a reliable reference basis for the evaluation of patients' prognosis.
陈华, 张继, 张波, 张红霞. 急性缺血性脑卒中取栓前后CT灌注成像与复发及认知功能的相关性分析[J]. 河北医学, 2022, 28(12): 2052-2057.
CHEN Hua, ZHANG Ji, ZHANG Bo, et al. Correlation between CT Perfusion Imaging and Recurrence and Cognitive Function before and after Thrombectomy in Acute Ischemic Stroke. HeBei Med, 2022, 28(12): 2052-2057.
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2022, Vol. 28 
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