Abstract：Objective: To explore the relationship between serum sex hormone binding globulin (SHBG), β-human chorionic gonadotropin (β-HCG), hypoxia-inducible factor-1α (HIF-1α) and gestational diabetes mellitus (GDM) and adverse pregnancy outcomes. Methods: A total of 112 pregnant women with GDM who were admitted to our hospital from October 2019 to October 2021 were selected as the observation group, and another 50 healthy pregnant women who underwent pregnancy tests during the same period were selected as the control group. The serum levels of SHBG, β-HCG and HIF-1α and the occurrence of adverse pregnancy outcomes were detected and compared between the two groups of research subjects, and the levels of serum SHBG, β-HCG and HIF-1α in pregnant women with different pregnancy outcomes were analyzed. Results: Compared with the healthy control group, the serum SHBG levels of pregnant women in the GDM group were significantly decreased, while the levels of β-HCG and HIF-1α were significantly increased (P<0. 05). The total incidence of adverse pregnancy outcomes in the observation group (42. 86%) was significantly higher than that in the control group (14. 00%) (P<0. 05). The serum SHBG level in the adverse pregnancy group was lower than that in the normal pregnancy group, and the levels of β-HCG and HIF-1α were higher than those in the normal pregnancy group (P<0. 05). Conclusion: Serum SHBG, β-hCG and HIF-1α are related to the occurrence of GDM, and may affect the outcome of pregnancy, which should be paid attention to in early pregnancy examination.
2022, Vol. 28 
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