Effect of Modified Ginseng Yangrong Decoction on the Expression of Tumor Markers and Th1/Th2 Cytokines in Pelvic Recurrent Cervical Cancer during Concurrent Radiotherapy and Chemotherapy
PENG Lei, QIN Hongen, HUANG Huabin, et al
The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Hubei Enshi 445000, China
摘要目的: 探讨加味人参养荣汤对盆腔复发性宫颈癌同步放化疗期间肿瘤标志物和Th1/Th2型细胞因子影响。方法: 选择我院于2018年12月至2021年12月盆腔复发性宫颈癌患者102例,按入院顺序单双号1∶1比例分为观察组51例与对照组51例。对照组行同步放化疗治疗,观察组在同步放化疗基础上结合加味人参养荣汤治疗。两组均以21d为一个周期,连续治疗2个周期评价。比较两组近期疗效,治疗前后卡氏功能状态(KPS)评分、免疫功能、肿瘤标志物、Th1/Th2细胞因子变化,及毒副反应情况。结果: 观察组客观缓解率高于对照组(70.95% vs 50.98%,P<0.05)。观察组治疗后KPS评分高于对照组(89.80±2.44 vs 73.92±4.93,P<0.05)。观察组治疗后CD3+、CD4+和CD4+/CD8+高于对照组(58.79±3.01 vs 50.81±3.15、38.95±2.65 vs 31.29±3.07、1.62±0.21 vs 1.04±0.13,P<0.05)。观察组治疗后CEA、CA19-9和CYFRA21-1水平低于对照组(83.42±12.25 vs 115.26±20.39、18.94±5.46 vs 29.46±6.28、4.67±1.08 vs 6.58±1.25,P<0.05)。观察组治疗后IL-2、IL-10、TNF-α和IFN-γ水平低于对照组(12.26±2.87 vs 16.79±2.54、18.29±3.87 vs 25.46±3.34、15.47±4.12 vs 21.74±2.95、19.98±5.45 vs 32.24±6.65,P<0.05)。观察组毒副反应发生率低于对照组(11.76% vs 29.41%,P<0.05)。结论: 加味人参养荣汤对盆腔复发性宫颈癌同步放化疗期间疗效明显,提高免疫功能,降低肿瘤标志物CEA、CA19-9和CYFRA21-1水平,及调节Th1/Th2型细胞因子平衡。
Abstract：Objective: To investigate the effect of modified Ginseng Yangrong Decoction on the expression of tumor markers and Th1Th2 cytokines in pelvic recurrent cervical cancer during concurrent radiotherapy and chemotherapy. Methods: 102 patients with recurrent pelvic cervical cancer admitted to our hospital from December 2018 to December 2021 were selected, and divided into the observation group (n=51) and the control group (n=51) in the ratio of 1:1 according to the order of admission single and double numbers. The control group was treated with synchronous radiotherapy, while the observation group was treated with synchronous radiotherapy combined with addition of Ginseng Yangrong Decoction. 21d was set as a cycle for both groups, and 2 cycles of continuous treatment were evaluated. The recent efficacy, KPS score, immune function, tumour markers, Th1/Th2 cytokine changes and toxic side effects of the two groups were compared before and after treatment. Results: The objective remission rate was higher in the observation group than in the control group (70. 95% vs 50. 98%, P<0. 05). The KPS score after treatment was higher in the observation group than in the control group (89. 80±2. 44 vs 73. 92±4. 93, P<0. 05). CD3+, CD4+ and CD4+/CD8+ were higher in the observation group than in the control group after treatment (58. 79±3. 01 vs 50. 81±3. 15, 38. 95±2. 65 vs 31. 29±3. 07, 1. 62±0. 21 vs 1. 04±0. 13, P<0. 05). CEA, CA19-9 and CYFRA21-1 levels were lower in the observation group than in the control group after treatment (83. 42±12. 25 vs 115. 26±20. 39, 18. 94±5. 46 vs 29. 46±6. 28, 4. 67±1. 08 vs 6. 58±1. 25, P<0. 05). The post-treatment levels of IL-2, IL-10, TNF-α and IFN-γ were lower in the observation group than in the control group (12. 26±2. 87 vs 16. 79±2. 54, 18. 29±3. 87 vs 25. 46±3. 34, 15. 47±4. 12 vs 21. 74±2. 95, 19. 98±5. 45 vs 32. 24±6. 65, P< (0. 05). The incidence of toxic side effects in the observation group was lower than that in the control group (11. 76% vs 29. 41%, P<0. 05). Conclusion: Modified Ginseng Yangrong Decoction has obvious curative effect on pelvic recurrent cervical cancer during concurrent radiotherapy and chemotherapy, improves the immune function of patients, reduces the levels of tumor markers CEA, CA19-9 and CYFRA21-1, and regulates the balance of Th1/Th2 cytokines.
彭磊, 覃鸿恩, 黄华斌, 吴飞, 杨丹, 郑良栋, 漆立军. 加味人参养荣汤对盆腔复发性宫颈癌同步放化疗期间肿瘤标志物和Th1/Th2细胞因子表达水平的影响[J]. 河北医学, 2022, 28(12): 2002-2006.
PENG Lei, QIN Hongen, HUANG Huabin, et al. Effect of Modified Ginseng Yangrong Decoction on the Expression of Tumor Markers and Th1/Th2 Cytokines in Pelvic Recurrent Cervical Cancer during Concurrent Radiotherapy and Chemotherapy. HeBei Med, 2022, 28(12): 2002-2006.
2022, Vol. 28 
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