Abstract：Objective: To analyze of bacterial population spectrum and drug sensitivity in patients with chronic obstructive pulmonary disease (COPD).Methods: The sputum culture data of 212 patients with COPD were retrospectively analyzed between January 2018 and June 2022. The distribution characteristics and drug susceptibility test results of pathogens in sputum culture were analyzed. Results: There were 212 strains of pathogens isolated from sputum culture specimens, including 111 (52.36%) strains of Gram-negative bacteria, 9 (4.24%) strains of Gram-positive bacteria and 92 (43.40%) strains of fungi. In Gram-negative bacteria, proportion of Pseudomonas aeruginosa was the highest (23.11%), followed by Escherichia coli (8.02%). In Gram-positive bacteria, proportion of Streptococcus pneumoniae was the highest (1.89%). In fungi, proportion of Candida albicans was the highest (40.09%). The results of drug sensitivity test showed that Pseudomonas aeruginosa was 100% sensitive to colistin, and the resistance rate to other antibiotics was 6.12% ~ 28.57%; Escherichia coli was 100% sensitive to meropenem and tigecycline, and 94.12% sensitive to imipenem and ertapenem; Klebsiella was 100% sensitive to amikacin, piperacillin tazobactam, cefoperazone sulbactam, imipenem, meropenem, tigecycline and ertapenem, and the resistance rate to other antibiotics was 11.76% ~ 29.41%. Conclusion: The pathogenic bacteria of COPD are mainly Gram-negative bacteria, mainly Pseudomonas aeruginosa and Escherichia coli. It is recommended to refer to the results of drug sensitivity test.
2022, Vol. 28 
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