Abstract：Objective: To analyze the relationship between serum retinol-1 (Omentin-1) and non-traumatic osteonecrosis of the femoral head (NONFH).Methods: The study included 82 patients with NONFH as the patient group and 77 healthy subjects as the healthy group, and serum retinoid-1, total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) levels were measured in both groups. Serum omentin-1 levels were compared between different etiologies, ARCO stages, and before and after collapse, and the correlation between serum omentin-1 levels and disease severity and lipid levels was analyzed to assess the value of serum omentin-1 concentrations in disease assessment using ROC curves.Results: The level of serum retinin-1 in NONFH was significantly lower than that in healthy controls (P<0.01), but there was no significant difference among patients with osteonecrosis of the femoral head (P>0.05). The level of serum retinin-1 in patients with femoral head collapse was significantly lower than that before collapse (P<0.01). The level of serum retinin-1 in patients with bilateral disease was lower than that in patients with unilateral disease, but the difference was not statistically significant (P>0.05). There was a significant difference in the level of serum retinol-1 among patients with different ARCO stages, and the level of serum retinin-1 was negatively correlated with ARCO stage, VAS score and Harris score, and negatively correlated with TC, TG and HDL. ROC curve analysis showed that the level of serum retinin-1 had a certain significance in the diagnosis of NONFH. Conclusion: The decrease of serum retinol-1 level can reflect the severity of NONFH disease and has certain significance for the clinical diagnosis and treatment of NONFH.
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2022, Vol. 28 
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