Abstract：Objective: To explore the significance of chromosomal karyotype changes at different stages in the diagnosis, treatment, progression and prognosis of chronic myeloid leukemia(CML).Methods: From July 2019 to Deceber 2021, 167 newly diagnosed CML patients were treated in The First Affiliated Hosptital of Air Force Military Medical University. Chromosome preparation was made using 24 hours short-term culture of bone marrow cells, and R-banding technique was used for chromosome karyotype analysis. The genetic characteristics and significance of the disease were observed.And an analysis was conducted of the differences between chromosomal variant translocations and additional chromosomal abnormalities and classical Ph+ CML in the diagnosis and treatment of the disease. Results: In the 167 cases of CML patients, 104 cases was male, 63 cases was female, and the age range was between 11 and 86. By analyzing the karyotype of 167 cases CML pateints, 7 cases (4.2%) were non mitotic, 154 cases were Ph chromosome positive (Ph+) and 6 cases were Ph chromosome negative (Ph-). In the 154 cases of Ph+ pateints, 126 cases were classical Ph+ and 28 cases were variant rearrangements or additional chromosome abnormalities, include +8, +Ph, -Y, der (17), del (3p), del (15q), del (11p), add (21q), add (2q) and so on, the majority were +8, +Ph, -Y, der (17). Conclusion: In the chromosome karyotypic analysis of CML, Ph chromosome was the genetic marker. The complexity of chromosome karyotype is closely related to CML treatment, progress and prognosis. The more complexity of the chromosomes, the worse prognosis of the patient.
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2022, Vol. 28 
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