Abstract：Objective: To investigate the difference of dosimetry between anisotropic analytical algorithm (AAA) and acuros external Beam algorithm (AXB) to the SIB-VMAT for locally advanced esophageal squamous cell carcinoma. Methods: Twenty four patients with locally advanced esophageal squamous cell carcinoma who received SIB-VMAT radiotherapy were randomly selected.Two algorithms modes of AAA and AXB were used to design SIB-VMAT plans with the same beam,MLC and optimized constraint function,to compare the differences of dosimetry parameters between the two groups. Results: In terms of Dmax,Dmean,D98%,and D50% of the target area,the AXB group were significantly higher than those in the AAA group,which was statistically significant (P<0.05).The conformity index (CI) and homogeneity index (HI) of the AXB group were better than those of the AAA group for PGTV,with statistical significance (P<0.05),but there was no significant difference in the PTV (P>0.05).About the dose of lung,AXB group could effectively reduce the dose of Dmin,Dmean,D50% and V5,but V20 and Dmax were slightly higher than AAA,which was statistically significant (P<0.05).About the dose of cardiac,except V30 was lower than AAA (1.29%),and Dmax was slightly higher than AAA (0.82%),which was statistically significant (P<0.05).About the dose of spinal cord protection area,the Dmax of AXB group was slightly higher than AAA (0.59%),which was statistically significant (P<0.05).The monitor unit(MU) of the AXB group was slightly higher than AAA (1.53%),which was statistically significant (P<0.05). Conclusion: The SIB-VMAT plan optimized by the AAA and AXB algorithms can meet the clinical requirements.Although the AXB algorithm and the AAA algorithm have certain differences in the dose results of the SIB-VMAT planning model,they both meet the clinical dosimetry requirements and can be used for the clinical treatment of locally advanced esophageal squamous cell carcinoma by the SIB-VMAT.
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2022, Vol. 28 
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