The Role of Multiparametric Magnetic Resonance in the Assessment of the Pathological Nature and Molecular Subtypes of Non-Mass-Enhancing Lesions in the Breast
QIN Xiaoxue, XI Jiajia, XU Jia
Qinhuai Medical District,Eastern Theater General Hospital, Jiangsu Nanjing 210000, China
Abstract：Objective: To investigate the role of multiparametric MRI in the assessment of the pathological nature and molecular subtypes of non-mass-enhancing (NME) lesions of the breast. Methods: Twenty eight patients with NME admitted from January 2018 to December 2021 were selected and all underwent multiparametric MRI,including flat-scan 3D scrambled-phase fast gradient echo T1WI transaxial position,fat-suppressed T2WI transaxial position,dynamic enhanced magnetic resonance imaging (DCE-MRI),and diffusion-weighted imaging (DWI) scans.The patients were divided into malignant group (n=168) and benign group according to pathological findings.The baseline data and multiparametric MRI results of the two groups were compared,the value of multiparametric MRI in identifying malignant NME was analyzed using the receiver operating characteristic (ROC) curve,and the results of multiparametric MRI in patients with different molecular subtypes were compared. Results: In the malignant group,there were more patients with internal reinforcement clusters,segmental distribution and perineural oedema than in the benign group,and the ADC values were lower than in the benign group (P<0.05); the ROC curve showed that the combined diagnostic AUC of internal reinforcement clusters,segmental distribution,ADC values and perineural oedema was greater than that of any single parameter; the ADC values of HER-2 type were higher than those of Luminal A,Luminal B and TNBC types (P<0.05); the ADC values of HER-2 and TNBC types were higher than those of Luminal A and TNBC types (P<0.05).(P<0.05); more patients with HER-2 and TNBC types had peri-tumoural oedema than Luminal A and Luminal B types (P<0.05). Conclusion: Internal enhancement clusters,segmental distribution,ADC values and peri-tumoural oedema are of high diagnostic value for the pathological nature of NME lesions and can be used clinically to identify their benign and malignant nature and to assess their molecular subtypes,providing a reference basis for clinical treatment planning.
秦小雪, 席佳佳, 徐佳. 多参数磁共振在乳腺非肿块性强化病变病理性质及分子亚型中评估作用探究[J]. 河北医学, 2022, 28(10): 1731-1737.
QIN Xiaoxue, XI Jiajia, XU Jia. The Role of Multiparametric Magnetic Resonance in the Assessment of the Pathological Nature and Molecular Subtypes of Non-Mass-Enhancing Lesions in the Breast. HeBei Med, 2022, 28(10): 1731-1737.
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2022, Vol. 28 
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