Efficacy of Ceftriaxone Sodium Combined with Dexamethasone in the Treatment of Children with Purulent Meningitis and Its Effects on Serum IFN-γ and IL-4 Levels
ZHANG Jingjing, JIA Yuanyuan, HU Miaomiao, et al
The First Affiliated Hospital of the Military Medical University of the Chinese People's Liberation Army Air Force, Shaanxi Xi'an 710032, China
Abstract：Objective: To observe the efficacy of ceftriaxone sodium combined with dexamethasone in the treatment of purulent meningitis (PM) in children and the effects on levels of serum interferon (IFN-γ) and interleukin 4 (IL-4). Methods: Using the random remainder grouping method of random number table method, 96 children with PM who were admitted to the hospital from March 2019 to March 2022 were randomly divided into the observation group and the control group, with 48 cases in each group. Both groups were given basic symptomatic treatment, and the control group underwent ceftriaxone sodium therapy additionally while the observation group underwent ceftriaxone sodium + dexamethasone therapy additionally, and both group were treated for 2 weeks. After 2 weeks of treatment, the clinical efficacy and recovery status of symptoms and signs of the two groups were compared, and the levels of inflammatory factors and serum related factors were observed in the two groups before and after treatment. Results: After 2 weeks of treatment, the total clinical effective rate of the observation group was higher than that of the control group (97.92% VS 87.50%) (P<0.05). The fever abatement time, cerebrospinal fluid recovery time and recovery time of peripheral blood leukocyte of (2.34±0.76) d, (7.65±0.83) d and (5.24±1.27) d in the observation group were shorter than (3.62±0.81) d, (9.88±1.12) d and (7.18±2.03) d in the control group (P<0.05). After 2 weeks of treatment, serum levels of INF-γ, IL-4, TNF-α, PCT, MMP-9 and sB7-H3 in the two groups were lower than those before treatment, and the differences before and after treatment were statistically significant between the observation group [(4.31±1.08) pg/mL, (53.54±4.17) pg/mL, (91.85±19.90) ng/L, (12.51±2.68) ng/mL, (251.09±24.07) μg/L, (1850.66±269.54) ng/L] and the control group [(2.97±1.38) pg/mL, (45.83±0.38) pg/mL, (75.98±20.76) ng/L, (8.76±2.79) ng/mL, (204.51±18.88) μg/L, (1320.23±240.71) ng/L] (P<0.05). Conclusion: Ceftriaxone sodium+dexamethasone can shorten the recovery times of symptoms and signs, reduce the levels of inflammatory factors, and promote the rehabilitation of children with PM.
张静静, 贾媛媛, 胡苗苗, 成胜权. 头孢曲松钠联合地塞米松治疗小儿化脓性脑膜炎疗效及对血清IFN-γ IL-4水平的影响[J]. 河北医学, 2022, 28(10): 1636-1639.
ZHANG Jingjing, JIA Yuanyuan, HU Miaomiao, et al. Efficacy of Ceftriaxone Sodium Combined with Dexamethasone in the Treatment of Children with Purulent Meningitis and Its Effects on Serum IFN-γ and IL-4 Levels. HeBei Med, 2022, 28(10): 1636-1639.
2022, Vol. 28 
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