银杏叶提取物注射液联合多哌奈齐治疗老年血管性痴呆的效果及对认知功能氧化应激反应的影响

doi:10.3969/j.issn.1006-6233.2022.09.036

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摘要 目的: 探究银杏叶提取物注射液联合多哌奈齐治疗老年血管性痴呆的效果及对认知功能、氧化应激反应的影响。方法: 采用回顾性分析的方法以2019年5月至2021年12月我院收治的90例血管性痴呆老年患者资料作为本次研究对象,全部病例依据治疗方法不同被分为观察组(n=45)和对照组(n=45),对照组患者给予盐酸多奈哌齐片治疗,观察组给予盐酸多奈哌齐片与银杏叶提取物注射液联合治疗,全部患者连续治疗2个月。对比治疗前后的治疗效果、认知功能、自理能力以及氧化应激反应相关指标。结果: 观察组患者治疗总有效率显著高于对照组(P<0.05)。治疗后,两组MMES量表分及Barthel指数评分明显高于治疗前。治疗后,两组血清同型半胱氨酸(Hcy)、干扰素-γ(IFN-γ)、丙二醛(MDA)含量明显低于治疗前,两组超氧化物歧化酶(SOD)含量明显高于治疗前。结论: 银杏叶提取物注射液与多哌奈齐联合治疗血管性痴呆老年患者可以明显改善患者认知功能,提高生活自理能力,降低氧化应激反应指标含量,治疗效果显著,值得临床推广应用。

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	彭菲
	王瑞萍
	张薇
	马春媚

关键词 ：血管性痴呆, 多哌奈齐, 银杏叶提取物, 认知功能, 氧化应激反应

Abstract：Objective: To explore the effect of extract of ginkgo biloba leaves injection combined with donepezil on senile vascular dementia and its influence on cognitive function and oxidative stress. Methods: The data of 90 aged patients who had vascular dementia treatment in our hospital from May 2019 to December 2021 were retrospectively analyzed. All patients were divided into two groups, the observation group (n=45) and the control group (n=45), according to different treatment methods. People in the control group were administered donepezil hydrochloride tablets, while the people in the observation group were administered extract of ginkgo biloba leaves injection combined with donepezil hydrochloride tablets. All patients were treated continuously for 2 months. The therapeutic effect, cognitive function, self-care ability, and indexes related to oxidative stress were compared before and after treatment. Results: The total effective rate of treatment in the observation group was significantly higher than that in the control group (P<0.05). After treatment, the scores on the MMES scale and Barthel index in the two groups were significantly higher than those before treatment. After treatment, the contents of serum homocysteine (Hcy), interferon-γ (IFN-γ), and malondialdehyde (MDA) in both groups were significantly lower than those before treatment, while the contents of superoxide dismutase (SOD) in both groups were significantly higher than those before treatment. Conclusion: Extract of ginkgo biloba leaves injection combined with doxepinezi can improve the cognitive function of elderly patients with vascular dementia, improve self-care ability, and reduce the content of oxidative stress reaction index. The therapeutic effect is remarkable, and it is worthy of clinical application.

Key words： Ginkgetin glycoside Dopenezil extract of ginkgo biloba leaves injection Cognitive function Oxidative stress reaction

基金资助:辽宁省科学技术计划项目,(编号:2018225072)

通讯作者: 王瑞萍

引用本文:

彭菲, 王瑞萍, 张薇, 马春媚. 银杏叶提取物注射液联合多哌奈齐治疗老年血管性痴呆的效果及对认知功能氧化应激反应的影响[J]. 河北医学, 2022, 28(9): 1577-1581.
PENG Fei, WANG Ruiping, ZHANG Wei, et al. Effectiveness of Extract of Ginkgo Biloba Leaves Injection Combined with Doperidonezide in the Treatment of Vascular Dementia in the Elderly and Its Effect on Cognitive Function and Oxidative Stress Response. HeBei Med, 2022, 28(9): 1577-1581.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2022.09.036 或 http://www.hbyxzzs.cn/CN/Y2022/V28/I9/1577

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