金天格胶囊联合骨化三醇对骨质疏松性椎体压缩性骨折患者的应用效果分析

doi:10.3969/j.issn.1006-6233.2022.09.035

摘要
图/表
参考文献
相关文章 (13)

全文: PDF (1227 KB) HTML (1 KB)
输出: BibTeX | EndNote (RIS)

摘要 目的: 分析金天格胶囊联合骨化三醇对骨质疏松性椎体压缩性骨折(OVCF)患者的应用效果。方法: 选择我院2017年1月至2021年6月收治的150例OVCF患者,使用分层随机法分别纳入联合组、对照组,各75例。两组患者均接受经皮椎体成形术(PVP)治疗,对照组术后口服骨化三醇,联合组加用金天格胶囊口服,持续6个月。对比两组患者术前、用药后6个月疼痛视觉模拟评分(VAS)、Oswestry功能障碍指数(ODI)、椎体前缘高度、伤椎Cobb角、骨密度、骨代谢指标变化。结果: 两组用药后6个月VAS评分、ODI指数、Cobb角、RANKL均较术前下降,椎体前缘高度,L1~L4骨密度、股骨颈骨密度,OPG均较术前升高;联合组用药后6个月VAS评分、ODI指数、Cobb角、RANKL,以及椎体前缘高度、L1~L4骨密度、股骨颈骨密度、OPG变化差值均高于对照组,差异有统计学意义(P<0.05)。结论: 在骨化三醇的基础上,将金天格胶囊联合应用于OVCF患者PVP术后辅助治疗,不仅有助于缓解患者临床症状、促进椎体高度恢复,还可改善患者骨密度及骨代谢,实现标本兼治。

	服务

	把本文推荐给朋友
	加入我的书架
	加入引用管理器
	E-mail Alert
	RSS
	作者相关文章

关键词 ：金天格胶囊, 骨化三醇, 骨质疏松性椎体压缩性骨折, 骨代谢

Abstract：Objective: To analyze the effect of Jintiange capsule combined with calcitriol in patients with osteoporotic vertebral compression fracture (OVCF). Methods: Totally 150 patients with OVCF admitted to our hospital from January 2017 to June 2021 were randomly divided into the combined group and the control group with 75 cases in each group. Patients in both groups received percutaneous vertebroplasty (PVP), the control group was given calcitriol orally after the operation, and the combined group was given Jintiange capsule orally for 6 months. The changes in the visual analog scale of pain (VAS), Oswestry dysfunction index (ODI), the height of the anterior edge of the vertebral body, Cobb angle of injured vertebral body, bone mineral density, and bone metabolism index were compared between the two groups. Results: Six months after treatment, the VAS score, ODI index, Cobb angle, and RANKL of the two groups decreased compared with those before the operation, while the height of the vertebral front, the bone mineral density of L1~L4, the bone mineral density of femoral neck and OPG increased. The VAS score, ODI index, Cobb angle, RANKL, the height of the anterior edge of the vertebral body, the bone mineral density of L1~L4, the bone mineral density of the femoral neck, and OPG in the group were all higher than those in the control group at 6 months after combined treatment, and the difference was statistically significant (P<0.05). Conclusion: Based on oestriol, the combination of Jintiange capsules in the postoperative adjuvant treatment of OVCF patients with PVP not only helps to alleviate patients' clinical symptoms and promotes the recovery of vertebral height but also improves patients' bone density and bone metabolism, achieving both symptomatic and primary treatment.

Key words： Jintiange capsule Calcitriol Osteoporotic vertebral compression fracture Bone metabolism

基金资助:山西省卫生计生委科研课题,(编号:2018154)

引用本文:

仇志韬, 杨辉, 王文革, 秦国强, 张冰冰. 金天格胶囊联合骨化三醇对骨质疏松性椎体压缩性骨折患者的应用效果分析[J]. 河北医学, 2022, 28(9): 1573-1576.
QIU Zhitao,YANG Hui, WANG Wenge, et al. Analysis of Effect of Jintiange Capsule Combined with Calcitriol on Patients with Osteoporotic Vertebral Compression Fracture. HeBei Med, 2022, 28(9): 1573-1576.

链接本文:

http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2022.09.035 或 http://www.hbyxzzs.cn/CN/Y2022/V28/I9/1573

[1] 陈伟健,谢炜星,晋大祥,等.胸腰段骨质疏松性椎体压缩性骨折有限元模型的建立[J].山东医药,2018,58(32):55-58.
[2] Wang B,Zhao C P,Song L X,et al.Balloon kyphoplasty versus percutaneous vertebroplasty for osteoporotic vertebral compression fracture:a meta-analysis and systematic review[J].Journal of orthopaedic surgery and research,2018,13(1):1-8.
[3] 任志伟,尹思,王莹,等.经皮椎体后凸成形术治疗多节段骨质疏松性椎体压缩性骨折的疗效分析[J].实用骨科杂志,2018,24(7):633-637.
[4] 苏其昌,张汉庆,王晓慧.经皮球囊扩张椎体后凸成形术与保守治疗骨质疏松性椎体压缩性骨折的Meta分析[J].江汉大学学报:自然科学版,2018,46(1):77-82.
[5] Sun M,Hu L,Wang S,et al.Circulating microRNA-19b identified from osteoporotic vertebral compression fracture patients increases bone formation[J].Journal of Bone and Mineral Research,2020,35(2):306-316.
[6] 邢帅,杨勇,王永刚,等.脊柱骨盆矢状面平衡对骨质疏松性椎体压缩性骨折经皮椎体后凸成形术后继发骨折的影响[J].中华创伤骨科杂志,2018,20(6):487-491.
[7] Zhao W T,Qin D P,Zhang X G,et al.Biomechanical effects of different vertebral heights after augmentation of osteoporotic vertebral compression fracture:a three-dimensional finite element analysis[J].Journal of orthopaedic surgery and research,2018,13(1):1-10.
[8] Huang S,Zhu X,Xiao D,et al.Therapeutic effect of percutaneous kyphoplasty combined with anti-osteoporosis drug on postmenopausal women with osteoporotic vertebral compression fracture and analysis of postoperative bone cement leakage risk factors:a retrospective cohort study[J].Journal of orthopaedic surgery and research,2019,14(1):1-12.
[9] 项廷淼,殷世武,李靖,等.高黏度骨水泥治疗骨质疏松性椎体压缩性骨折的临床疗效观察[J].中国医学前沿杂志,2018,10(9):43-46.
[10] Jin Y Z,Lee J H,Xu B,et al.Effect of medications on prevention of secondary osteoporotic vertebral compression fracture,non-vertebral fracture,and discontinuation due to adverse events:a meta-analysis of randomized controlled trials[J].BMC musculoskeletal disorders,2019,20(1):1-17.
[11] Kim H J,Park S,Park S H,et al.Prevalence of frailty in patients with osteoporotic vertebral compression fracture and its association with numbers of fractures[J].Yonsei medical journal,2018,59(2):317-324.
[12] 李素艳,赵军红.骨质疏松性椎体压缩性骨折术后生活质量及危险因素分析[J].哈尔滨医药,2021,41(1):48-49.
[13] Ameis A,Randhawa K,Yu H,et al.The global spine care initiative:a review of reviews and recommendations for the non-invasive management of acute osteoporotic vertebral compression fracture pain in low-and middle-income communities[J].European Spine Journal,2018,27(6):861-869.
[14] Chiu P Y,Kao F C,Hsieh M K,et al.A retrospective analysis in 1347 patients undergoing cement augmentation for osteoporotic vertebral compression fracture:is the sandwich vertebra at a higher risk of further fracture[J].Neurosurgery,2021,88(2):342-348.