Abstract：Objective: To observe the effect of caffeine citrate combined with mild hypothermia on the levels of S100B and MMP-9 in premature infants with brain injury. Methods: A total of 60 premature infants with brain injury who were treated in the hospital from May 2018 to May 2021 were selected and randomly divided into 2 groups. 30 children in the control group were given basic treatment and caffeine citrate and 30 children in the experimental group were given basic treatment, caffeine citrate combined with sublimation. The levels of S100B, matrix metalloproteinase-9 (MMP-9), neurofilament protein H phosphorylated isoform (pNF-H), glial fibrillary acidic protein (GFAP), tumor necrosis factor-α (TNF-α), Toll-like receptor-4 (TLR-4), interleukin-1β (IL-1β), superoxide dismutase (SOD), lipid peroxide (P-LPO) and reactive oxygen species (ROS) were measured before and after treatment. The levels of lipid peroxide (P-LPO) and reactive oxygen species (ROS) were recorded, and the time to recovery of primitive reflexes, time to recovery of muscle tone, time to recovery of consciousness, time to voluntary suckling, and days of hospitalization were recorded in both groups. Results: The level of TNF-α, TLR-4, and IL-1β were lower in the experimental group than in the control group (P<0.05), the level of SOD was higher in the experimental group than in the control group (P<0.05), the level of P-LPO and ROS were lower in the experimental group than in the control group (P<0.05), and the level of S100B, MMP-9, pNF-H, and GFAP water was lower in the experimental group than in the control group (P<0.05). The time to recovery of primitive reflexes, time to recovery of muscle tone, time to recovery of voluntary suckling, time to recovery of consciousness, and days of hospitalization were shorter in the test group than in the control group (P<0.05), and the NB-NA elevation score was higher in the test group than in the control group (P<0.05). Conclusion: Compared with the basic treatment and caffeine citrate treatment, the combination of caffeine citrate and subhypothermia treatment for preterm infants with brain injury can reduce inflammatory factors in the body, inhibit the inflammatory response, improve patients' oxidative stress levels, reduce oxygen-free radical damage, reduce S100B, MMP-9, pNF-H, and GFAP levels, enhance patients' neurological function and promote their recovery.
季菊花, 洪菲, 宋磊. 枸橼酸咖啡因联合亚低温对脑损伤早产儿S100B MMP-9水平的影响[J]. 河北医学, 2022, 28(9): 1506-1510.
JI Juhua, HONG Fei, SONG Lei. Effects of Caffeine Citrate Combined with Mild Hypothermia on the Levels of S100B and MMP-9 in Premature Infants with Brain Injury. HeBei Med, 2022, 28(9): 1506-1510.
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2022, Vol. 28 
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