Efficacy of Probiotic-Assisted Estramiprazole-Based Quadruple Regimen in the Treatment of Hp-Positive Gastric Ulcer and Analysis of the Effect on Intestinal Flora
YIN Yuanying, GAO Lisha, LIU Yan, et al
The West China Hospital, Sichuan University, Sichuan Chengdu 610041, China
Abstract：Objective: To investigate the efficacy of a probiotic-assisted quadruple regimen based on esomeprazole in the treatment of Helicobacter pylori (H. pylori, Hp) positive gastric ulcer and its effect on the intestinal flora. Methods: A total of 123 patients with Hp-positive gastric ulcers who were admitted to our hospital from May 2019 to May 2021 were selected for research, and they were divided into a study group (N=63) and a control group (N=60) by a simple random method using a random number table. The group was treated with a quadruple regimen based on esomeprazole, and the research group was given probiotics (Saccharomyces boulardii) on this basis. Both groups were treated for 14 days, and the Hp eradication rate, ulcer surface healing, intestinal flora, and adverse effects between the two groups were compared. Results: The rate of ulcer surface healing and Hp eradication were higher in the study group than in the control group, with statistically significant differences (P<0.05). The levels of Clostridium perfringens, Bifidobacterium, and Lactobacillus were lower in the control group than before treatment (P<0.05), while the levels of Enterobacter, Yeast, and Enterococcus were higher (P<0.05) and the B/E values were lower (P<0.05). The levels of Bifidobacterium and Lactobacillus in the study group were higher than before treatment (P<0.05), the levels of Clostridium perfringens were lower than before treatment (P<0.05), and the levels of Enterobacter, Enterococcus and Yeast were not significantly different from before treatment (P>0.05). Conclusion: The probiotic-assisted estramiprazole-based quadruple regimen for the treatment of patients with H. pylori Hp-positive gastric ulcers significantly improves clearance rates, promotes healing of the ulcer surface, and has a positive effect on promoting a balanced intestinal flora environment, making it suitable for promotion.
尹袁英, 高莉莎, 刘燕, 乔江蓉, 任宏飞, 张铭光. 益生菌辅助基于艾司奥美拉唑的四联方案治疗Hp阳性胃溃疡的疗效及对肠道菌群的影响分析[J]. 河北医学, 2022, 28(9): 1498-1501.
YIN Yuanying, GAO Lisha, LIU Yan, et al. Efficacy of Probiotic-Assisted Estramiprazole-Based Quadruple Regimen in the Treatment of Hp-Positive Gastric Ulcer and Analysis of the Effect on Intestinal Flora. HeBei Med, 2022, 28(9): 1498-1501.
[1] Palamides P, Jolaiya T, Idowu A,et al.Helicobacter pylori patient isolates from south africa and nigeria differ in virulence factor pathogenicity profile and associated gastric disease outcome[J].Scientific Reports,2020,10(1):11409. [2] Wang B, Zhang J, Chen S,et al.Helicobacter pylori and gastrointestinal and neurological diseases:study protocol of an umbrella review of systematic reviews and meta-analyses[J].Medicine,2019,98(52):e18460. [3] 闫小妮,屈彦,姚晚侠,等.铋剂四联疗法联合不同药物对幽门螺杆菌感染的疗效[J].中国微生态学杂志,2019,31(8):910-914. [4] 马佩炯、钟锦海、蔡伟、李文芳、吴和顺.肠道菌群移植,益生菌分别联合美沙拉嗪对轻,中度溃疡性结肠炎肠道屏障功能的影响[J].实用医院临床杂志,2020,17(6):84-87. [5] 张灵云,蓝宇,王玘,等.益生菌联合铋剂四联方案根除幽门螺杆菌的临床效果[J].中国临床医生杂志,2020,48(6):45-47. [6] 陈爱方,田霞,韩峥,等.质子泵抑制剂与小肠细菌过度生长的相关性及双歧杆菌三联活菌胶囊疗效观察[J].临床消化病杂志,2019,31(3):159-162. [7] 张茹,李园,马金霞,等.长期维持质子泵抑制剂治疗对老年人小肠细菌过度生长的影响分析[J].中华内科杂志,2020,59(9):706-710. [8] Namdev A,Jain D.Floating drug delivery systems:an emerging trend for the treatment of peptic ulcer[J].Current Drug Delivery,2019,16(10):874-886.
2022, Vol. 28 
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