Abstract：Objective: To explore the clinical significance of serum microRNA-17 (miR-17) and miR-25 expression in patients with preeclampsia (PE) and its influence on pregnancy outcome.Methods: Seventy-four cases of PE patients in our hospital from February 2018 to August 2020 were selected as the PE group, and 74 cases of normal pregnant women without pregnancy comorbidities and complications were selected as the healthy group during the same period. The general data and serum miR-17 and miR-25 levels of the two groups were compared, and the diagnostic value of serum miR-17 and miR-25 levels in relation to the occurrence of PE level on PE was analyzed, and the correlation between serum miR-17 and miR-25 levels and clinical characteristics and pregnancy outcome of PE patients was analyzed. Results: The diastolic blood pressure, systolic blood pressure, and serum miR-17 levels in the PE group were higher than those in the healthy group, and week of delivery, neonatal birth weight, and serum miR-25 levels were lower than in the healthy group (P<0.05); logistic regression analysis showed that serum miR-17 and miR-25 levels were correlated with PE (P<0.05);receiver operating characteristic (ROC) curve shows that the AUC for the combined diagnosis of PE with miR-17 and miR-25 was the largest at 0.918; there were significant differences in diastolic blood pressure, systolic blood pressure, gestational week of delivery, and neonatal birth weight among patients with PE with different serum miR-17 and miR-25 levels (P<0.05); miR-17 and miR-25 expression levels were associated with clinical characteristics (diastolic blood pressure, systolic blood pressure) and pregnancy outcome (gestational week of delivery, neonatal birth weight (P<0.05).Conclusion: Serum miR-17 and miR-25 of PE patients are expressed pathologically, and they are related to the severity of the disease and pregnancy outcome.
2022, Vol. 28 
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