Evaluation of the Efficacy and Safety of GnRH-a in Combination with Ursamine in the Treatment of Adenomyosis by Hysteroscopic Endometrial Electrosurgery
ZHU Yuanyuan, ZHANG Lei, YANG Yijun
Huai 'an First People's Hospital, Jiangsu Huai 'an 223000, China
Abstract：Objective: To explore the efficacy and safety of GnRH-a combined with ursamine in the treatment of adenomyosis by hysteroscopic endometrial resection.Methods: 107 patients with adenomyosis treated in our hospital from March 2016 to March 2021 were selected and randomly divided into control group (53 cases, subcutaneous injection of 3.75mg GnRH-a, once / 4 weeks, a total of 3 months) and observation group (54 cases, subcutaneous injection of 3.75mg GnRH-a, once / 4 weeks + ursamine, 1 tablet/time, stopped for 7 days after 21 days, a total of 3 months). The pain score, uterine volume, menstrual volume, and ovarian function were counted before operation and 3 months after treatment. The clinical efficacy after 3 months of treatment and adverse reactions during treatment were counted. The recurrence within 12 months was counted. Results After 3 months of treatment, the levels of vas, uterine volume, PBAC, FSH, and LH in the observation group were lower than those in the control group (P<0.05). The curative effect of the observation group was better than that of the control group (P<0.05). The total incidence and recurrence rate of adverse reactions in the observation group were lower than those in the control group (P<0.05). Conclusion: The follow-up treatment of adenomyosis with GnRH-a combined with ursamine after hysteroscopic endometrial resection is effective, which effectively alleviates the degree of dysmenorrhea, and restores ovarian function, reduces the incidence of postoperative adverse reactions, and reduces the recurrence rate to a certain extent.
朱元媛, 张磊, 杨一君. GnRH-a联合优思明对子宫腺肌症行宫腔镜子宫内膜电切术治疗疗效影响和安全性评价[J]. 河北医学, 2022, 28(8): 1303-1306.
ZHU Yuanyuan, ZHANG Lei, YANG Yijun. Evaluation of the Efficacy and Safety of GnRH-a in Combination with Ursamine in the Treatment of Adenomyosis by Hysteroscopic Endometrial Electrosurgery. HeBei Med, 2022, 28(8): 1303-1306.
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2022, Vol. 28 
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