Abstract：Objective: To analyze the correlation between type 2 diabetes mellitus (T2DM) and urinary stone species. Methods: One hundred and sixty-five patients with urinary calculi treated admitted in our hospital from January 2019 to December 2021 were enrolled for the research and divided into T2DM group (n = 35) and non-T2DM group (n = 130) according to the occurrence of T2DM before operation. The stone components were analyzed and compared between the two groups by infrared spectroscopy, and the influencing factors of uric acid stones were analyzed by logistic multivariate regression. Results: Calcium oxalate was the most common type of stones in T2DM group and non-t2dm patients, accounting for 48.5% (17/35) and 66.2% (86/130) respectively, followed by uric acid stones, accounting for 28.6% (10/35) and 10.0% (13/130) respectively. There was significant difference in the stone components between the two groups (P < 0.05), and the proportion of uric acid stones in T2DM group was significantly higher than that in non-T2DM group, but there were no significant differences in the proportions of other three stone components between two groups. We further divided all 165 patients with urinary calculi into uric acid calculi group (n = 23) and non-uric acid calculi group (n = 142). The age, body mass index, proportion of hypertension history, proportion of T2DM history, fasting blood glucose, blood triglyceride, uric acid, albumin and serum creatinine (SCr) levels in the uric acid stone group were significantly higher than those in the non-uric acid stone group, and the urine pH in uric acid stone group was significantly lower than that in non-uric acid stone group (P < 0.05). Result of multivariate logistic regression analysis showed that T2DM, blood uric acid, SCr level and urinary pH were the independent influencing factors of uric acid stones (P < 0.05). Conclusion: The stone species of patients with urinary calculi is related to T2DM, and patients with T2DM are more prone to uric acid stones, which is worthy of clinical attention.
2022, Vol. 28 
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