Abstract：Objective: To analyze the relationship between CT signs and clinicopathological characteristics in patients with multifocal lung adenocarcinoma with ground-glass nodules (MLA). Methods: A total of 80 patients with MLA confirmed by pathology in the hospital between July 2018 and August 2021 were included as the research subjects. A total of 203 lesions were detected and divided into preinvasive lesion group (92 nodules), microinvasive adenocarcinoma group (69 nodules) and invasive adenocarcinoma group (42 nodules). CT examination was performed on all patients, and the CT signs and clinicopathological characteristics of the three groups were analyzed. Results: There were statistical differences in nodule morphology, lobular sign, vacuole sign, spicule sign, air bronchogram, pleural indentation, tumor-lung interface, vascular characteristics and ground-glass nodule types among preinvasive lesion group, microinvasive adenocarcinoma group and invasive adenocarcinoma group (P<0.05). The proportions of round/elliptical nodules, lobular sign, vacuole sign, spicule sign, air bronchogram, pleural indentation, clear tumor-lung interface, vascular crossing sign and some solid nodules of invasive adenocarcinoma group were higher than those of the other two groups (P<0.05), and the proportions of vacuole sign, spicule sign, pleural indentation, vascular crossing sign and some solid nodules of microinvasive adenocarcinoma group were higher than those of preinvasive lesion group (P<0.05). There were statistically significant differences in the average size of nodules and average size of solid nodules among preinvasive lesion group, microinvasive adenocarcinoma group and invasive adenocarcinoma group (P<0.05), and further pairwise comparison showed that the two indicators of invasive adenocarcinoma group were larger than those of the other two groups (P<0.05), but there were no statistical differences between preinvasive lesion group and microinvasive adenocarcinoma group (P>0.05). Conclusion: CT signs of patients with MLA are closely related to pathological characteristics, and can provide a basis for clinical diagnosis and pathological classification.
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2022, Vol. 28 
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