Clinical Study on Acupuncture and Moxibustion Combined with Huanglian Wendan Decoction in the Treatment of Stroke Sleep Disorder with Phlegm Heat Disturbing Heart Syndrome
SU Guochun, ZHONG Haiyan, WEI Yin, et al
Qinzhou First People's Hospital,Guangxi Qinzhou 535000, China
Abstract：Objective: To study the clinical efficacy of acupuncture and moxibustion combined with Huanglian Wendan Decoction in the treatment of stroke sleep disorder with phlegm heat disturbing heart syndrome. Methods: Totally 100 stroke patients admitted to the First People's Hospital of Qinzhou City from July 2019 to June 2020 were collected and divided into a study group and a control group, 50 cases each. Control group was treated with Huanglian Wendan Decoction, and the study group was treated with acupuncture and moxibustion combined with Huanglian Wendan Decoction, with 4 weeks as 1 course of treatment for 3 courses. The clinical efficacy of the two groups were compared, the score of TCM symptoms was evaluated, and the TCM symptom score, sleep quality by polysomnography, and neurotrophic factor levels by enzyme immunoassay were assessed before and after treatment to observe the occurrence of adverse effects.Results: The total effective rate was 94.00% in the study group, higher than that of the control group at 76.00% (P<0.05). After treatment, the TCM symptom scores (sleep disturbance, distraction and chagrin, dizziness and chest tightness, red tongue with yellow coating), as well as sleep latency, rapid eye movement sleep time, wakefulness time and Pittsburgh Sleep Quality Index score (PSQI) were lower in both groups than before treatment, and the above indicators were lower in the study group than in the control group, and the difference was statistically significant (P<0.05). After treatment, the total sleep time and serum levels of brain-derived neurotrophic factor (BDNF), glial cell-derived neurotrophic factor (GDNF) and nerve growth factor (NGF) in both groups were higher than those before treatment, and all these indexes in the study group were higher than those in the control group, and the difference was statistically significant (P<0.05). The incidence of adverse reactions during the treatment period was 14.00% and 10.00% in the study group and the control group respectively, with no difference between the groups (P>0.05). Conclusion: The combination of acupuncture and moxibustion with Huang Lian Wen Bile Tang was effective in treating patients with sleep disorders in stroke with phlegm-heat disturbing the heart, improving the patients' TCM symptoms and sleep quality, and increasing the level of neurotrophic factors in stroke patients with better treatment safety.
苏国春, 种海燕, 韦殷, 吴昊锋, 潘静. 针灸联合黄连温胆汤治疗痰热扰心证脑卒中睡眠障碍的临床研究[J]. 河北医学, 2022, 28(4): 694-698.
SU Guochun, ZHONG Haiyan, WEI Yin, et al. Clinical Study on Acupuncture and Moxibustion Combined with Huanglian Wendan Decoction in the Treatment of Stroke Sleep Disorder with Phlegm Heat Disturbing Heart Syndrome. HeBei Med, 2022, 28(4): 694-698.
[1] 马芹颖,李冰,许勇,等.脑卒中筛查目标人群低睡眠质量现况及其影响因素分析[J].中国全科医学,2020,23(36):4609~4614. [2] 李庆兵,李凌鑫,罗才贵.脑卒中后睡眠障碍的中医理论探析[J].天津中医药大学学报,2019,38(1):1092~1094. [3] 李红星,马艳萍,付春红.黄连温胆汤治疗痰热内扰型失眠的效果观察[J].中医临床研究,2019,11(16):2~4. [4] 余李强,刘芳,沈翠玲,等.艾灸治疗脑卒中后睡眠障碍效果的系统评价[J].贵州中医药大学学报,2020,42(1):2798~2802. [5] 中国老年医学学会急诊医学分会,中华医学会急诊医学分会卒中学组,中国卒中学会急救医学分会,等.急性缺血性脑卒中急诊急救中国专家共识(2018)[J].临床急诊杂志,2018,19(6):351~359. [6] 闫改霞,白振军,宋雅琴,等.邢氏针法联合黄连温胆汤加减治疗对痰热内扰型中风后失眠症睡眠、疲劳和生活质量的影响[J].中华中医药学刊,2021,39(10):243~246. [7] 刘志喜,石倩萍,杨洪霞,等.匹兹堡睡眠质量指数量表在护理人群中的信效度评价[J].汕头大学医学院学报,2020,33(3):198~201. [8] Dong X,Zhang R,Guo Y,et al.The efficacy of Qigong exercises for post-stroke mental disorders and sleep disorders:protocol for a systematic review and meta-analysis[J].Medicine,2020,99(13):882~889. [9] 黄琳,王志军.小脑顶核电刺激联合常规疗法治疗脑卒中后睡眠障碍的观察[J].实用中西医结合临床,2019,29(5):11~12. [10] 徐珊珊,曾友华,包烨华.针灸通督法联合黄连温胆汤对脑卒中患者外周血miR-132,miR-134的影响[J].中国现代医生,2019,57(24):2671~2675. [11] Turkmen BA,Yazici E,Erdogan DG,et al.BDNF,GDNF,NGF and Klotho levels and neurocognitive functions in acute term of schizophrenia[J].BMC Psychiatry,2021,21(1):562.
2022, Vol. 28 
冀公网安备13080202000677号