Abstract：Objective: To evaluate the efficacy of four kinds of antipsychotic treatment of schizophrenia and the treatment of liver and blood lipid changes. Method: 160 patients with schizophrenia who were enrolled from January 2015 to February 2016 were randomly divided into four groups: risperidone, quetiapine, olanzapine and aripiprazole group, respectively. Treatment efficiency, PANSS score before and after treatment, blood lipid levels, fatty liver and adverse drug reactions. Result: There was no significant difference between the four groups in the overall treatment rate and the overall incidence of fatty liver, and there was no statistical significance (P>0.05); After olanzapine treatment, the total score of PANSS group was significantly lower than that of quetiapine group; The levels of TC, TG and LDL in the quetiapine group were significantly higher than those in the other three groups, and the levels of TG and LDL in the olanzapine group were significantly lower than those in the risperidone group and the aripiprazole group; The incidence of other adverse reactions in quetiapine group was significantly higher than that of the other three groups, there was significant difference (P<0.01). Conclusion: Four kinds of dugs can be effective antipsychotics in the treatment of schizophrenia, but quetiapine on blood lipid influence, adverse reaction rate is the highest, while the relative efficacy of olanzapine on lipid stability, small adverse reaction rate is the lowest, so it can be recommended as the primary drug.
2017, Vol. 23 
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