Abstract：Objective: To investigate the correlation between abnormal glycosylation of IgA1 molecule and Th17 cells in patients with IgA nephropathy. Methods: The clinical data of 50 patients with IgA nephropathy (IgA nephropathy group) and 50 healthy people (healthy control group) were selected for retrospective analysis. The patients’ admission period was from February 2018 to May 2020. Th17 cells, Treg cells, Gd-IgA1, TGF-β, IL-6, IL-17, IL-21, IL-23, serum creatinine, albumin and urine protein quantification were compared; Pearson method was used to analyze Gd-IgA1 and Th17 correlation of cells, Treg cells, and correlation of cytokines with Gd-IgA1. Results: Th17 cells, Th17/Treg, Gd-IgA1, IL-6, IL-17, IL-21, IL-23, serum creatinine and urine protein in the IgA nephropathy group were all higher than those in the healthy control group, while Treg cells, TGF-β and albumin were lower than the healthy control group (P＜0.05). Pearson correlation showed that Gd-IgA1 was positively correlated with Th17 cells and Th17/Treg (r=0.737/0.810, P＜0.05), and negatively correlated with Treg cells (r=-0.487, P＜0.05). Gd-IgA1 was negatively correlated with TGF-β (r=-0.260, P＜0.05), and positively correlated with IL-6, IL-17, IL-21, and IL-23 (r=0.796/0.776/0.714/0.819, P<0.05). Conclusion: In patients with IgA nephropathy, Th17 cells are positively correlated with Gd-IgA1, and the expression of Th17 cells can be evaluated to provide a basis for clinical diagnosis and treatment.
2022, Vol. 28 
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