Efficacy of High-Intensity Focused Ultrasound Ablation in the Treatment of Uterine Fibroids and Its Influence on Levels of Serum VEGF and ER and Pregnancy Outcomes
FAN Jingchun, JI Yanqin
Huizhou Central People's Hospital, Guangdong Huizhou 516001, China
Abstract：Objective: To study the efficacy of high-intensity focused ultrasound ablation on uterine fibroids and its influence on levels of serum vascular endothelial growth factor (VEGF) and estrogen receptor (ER) and pregnancy outcomes. Methods: Totally 121 patients with uterine fibroids of childbearing age admitted to the hospital from January 2019 to September 2020 were selected as the research subjects, and they were divided into control group (n=61) and observation group (n=60) according to the medical advices, progression of disease and patients’ desires. The control group was treated with conventional conservative drugs, and the observation group underwent high-intensity focused ultrasound ablation. The efficacy, uterine volume and uterine fibroids volume, levels of serum VEGF, ER and estradiol (E2) and postoperative pregnancy were compared between the two groups after treatment. Results: Before implementing the corresponding treatments, there were no significant differences in the uterine volume, uterine fibroids volume and levels of serum VEGF, ER and E2 between the two groups (P>0.05). After treatment, the uterine volume, uterine fibroids volume and levels of serum VEGF, ER and E2 were decreased in the two groups, and the difference of the above indexes in the observation group before and after treatment was significantly greater than that in the control group (P<0.05). After treatment, the efficacy and postoperative pregnancy of observation group were better than those of control group (P<0.05). Conclusion: High-intensity focused ultrasound ablation has a significant efficacy on uterine fibroids. It can reduce the levels of serum VEGF and ER and the volume of uterus andvolume of uterine fibroids, and it has a significant effect and the pregnancy outcomes of observation group are better than control group. Thus this kind of treatment method has clinical promotion value.
范景纯, 纪燕琴. 高强度聚焦超声消融术治疗子宫肌瘤的疗效及对血清VEGF ER水平妊娠结局的影响[J]. 河北医学, 2022, 28(3): 482-486.
FAN Jingchun, JI Yanqin. Efficacy of High-Intensity Focused Ultrasound Ablation in the Treatment of Uterine Fibroids and Its Influence on Levels of Serum VEGF and ER and Pregnancy Outcomes. HeBei Med, 2022, 28(3): 482-486.
2022, Vol. 28 
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