Abstract：Objective: To explore the clinical characteristics and related influencing factors of depression and cognitive dysfunction in patients with Parkinson's disease (PD). Methods: A total of 117 PD patients treated in the hospital from January 2019 to June 2020 were enrolled as the research subjects. The depression of patients was evaluated by Hamilton Depression Scale (HAMD), and the clinical characteristics and influencing factors of depression were analyzed. The cognitive status of patients was assessed by Montreal Cognitive Assessment (MOCA), and the clinical characteristics and influencing factors of cognitive dysfunction were analyzed. Results: The average score of HAMD and detection rate of depression were (17.64±3.26) points and 58.12%, respectively. Depression was related to course of disease, Hoehn-Yahr staging, education level and MoCA score (P<0.05). The results of multivariate Logistic regression analysis showed that course of disease, Hoehn-Yahr staging, education level and MoCA score were independent influencing factors of depression (P<0.05). The average score of MoCA and detection rate of cognitive dysfunction were (26.25±3.82) points and 53.85%, respectively. Cognitive dysfunction was related to gender, course of disease, age, Hoehn-Yahr staging, onset symptoms (festination, freezing, salivation and postural hypotension) and MoCA score (P<0.05). The results of multivariate Logistic regression analysis showed that Hoehn-Yahr staging and MoCA score were independent influencing factors of cognitive dysfunction (P<0.05). Conclusion: The detection rates of depression and cognitive dysfunction are relatively high in patients with Parkinson's disease. Depression is easily affected by course of disease, Hoehn-Yahr staging, education level, and MoCA score, while cognitive dysfunction is easily affected by Hoehn-Yahr staging and HAMD score, which deserves attention.
曾敏, 李梦岚, 陈静, 李银萍. 帕金森患者抑郁及认知功能障碍的临床特点及相关因素分析[J]. 河北医学, 2022, 28(3): 465-472.
ZENG Min, LI Menglan, CHEN Jing, et al. Clinical Characteristics and Related Factors of Depression and Cognitive Dysfunction in Patients with Parkinson's Disease. HeBei Med, 2022, 28(3): 465-472.
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2022, Vol. 28 
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