Abstract:Objective: To observe application effect of antibiotic bone cement technology in the treatment of Wanger 2-4 diabetic foot (DF). Methods: A total of 40 patients with Wanger 2~4 DF were selected and randomly divided into 2 groups by random number table method, with 20 cases in each. The control group was treated with vacuum sealing drainage (VSD). On this basis, the experimental group was treated with antibiotic bone cement. Before and after treatment, scores of American Orthopaedic Foot and Ankle Society (AOFAS) and visual analog scale (VAS) were compared between the two groups. The related indexes at 7d after treatment, hospitalization time, treatment cost and complications in the 2 groups were observed. Results: At 3 months after treatment, AOFAS score in the experimental group was significantly higher, while VAS score was significantly lower, than the control group (P<0.05). The coverage rate of granulation tissue and survival rate of stage II wound repair in experimental group were significantly higher than those in control group (P<0.05). The hospitalization time in experimental group was significantly shorter than that in control group (P<0.05), and wound infection rate and total treatment cost were significantly lower than those in control group (P<0.05). Conclusion: The application of antibiotic bone cement technology in treatment of Wanger 2-4 DF can effectively promote recovery of ankle-hind foot function and pain, shorten rehabilitation process and reduce treatment cost.
[1] Ahmed A,Getti G,Boateng J.Ciprofloxacin-loaded calcium alginate wafers prepared by freeze-drying technique for potential healing of chronic diabetic foot ulcers[J].Drug delivery and translational research,2018,8(6):1751~1768. [2] Pitocco D,Spanu T,Di Leo M,et al.Diabetic foot infections:a comprehensive overview[J].Eur Rev Med Pharmacol Sci,2019,23(2 Suppl):26~37. [3] Toscano CM,Sugita TH,Rosa MQM,et al.Annual direct medical costs of diabetic foot disease in brazil:a cost of illness study[J].Int Environ Res Public Health,2018,15(1):E89. [4] 黄红军,牛希华,杨冠龙,等.抗生素骨水泥在糖尿病足溃疡创面应用的临床效果[J].中华烧伤杂志,2019,35(6):464~466. [5] 中华医学会糖尿病学分会.中国2型糖尿病防治指南(2017年版)[J].中华糖尿病杂志,2018,10(1):4~67. [6] Lachiewicz PF,Wellman SS,Peterson JR.Antibiotic cement spacers for infected total knee arthroplasties[J].Am Acad Orthop Surg,2020,28(5):180~188. [7] Tantawy SA,Abdelbasset WK,Kamel DM,et al.A randomized controlled trial comparing helium-neon laser therapy and infrared laser therapy in patients with diabetic foot ulcer[J].Lasers in medical science,2018,33(9):1901~1906. [8] Pehde CE,Bennett J,Kingston M.Orthoplastic approach for surgical treatment of diabetic foot ulcers[J].Clin Podiatr Med Surg,2020,37(2):215~230. [9] Bai XG,Wang J,Li X,et al.A protocol of systematic review and meta-analysis of continuous vacuum sealing drainage for diabetic foot ulcer[J].Medicine (Baltimore),2020,99(25):e20541. [10] Jiang X,Li N,Yuan Y,et al.Limb salvage and prevention of ulcer recurrence in a chronic refractory diabetic foot osteomyelitis[J].Diabetes Metab Syndr Obes,2020,13:2289~2296. [11] 张苏岭,罗勇健,彭启华.抗生素骨水泥填塞联合封闭负压引流治疗糖尿病足并感染创面的效果观察[J].中国骨与关节损伤杂志,2020,35(8):877~879.