Effect of Clopidogrel Combined with Butylbenzene Peptide on Serum Levels of VEGF bFGF Ang-1 and Cognitive Function in Patients with Acute Cerebral Infarction
NIU Xiang, WANG Benxiao, BU Hongwei
Anhui Wanbei Coal and Electricity Group General Hospital, Anhui Suzhou 234000, China
Abstract：Objective: To investigate the effect of clopidogrel combined with butylbenzene peptide on serum levels of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiopoietin-1 (Ang-1) and cognitive function in patients with acute cerebral infarction (ACI). Methods: One hundred and fifty-two patients with ACI admitted to Anhui Wanbei Coal and Electricity Group General Hospital from January 2018 to May 2020 were collected and divided into observation group (n=76) and control group (n=76) with simple random grouping method. Patients in the control group were given routine treatment and clopidogrel. On this basis, patients in observation group were given butylbenzene peptide capsule. The score of National Institutes of Health Stroke Scale (NIHSS), Montreal Cognitive Assessment (MoCA), serum levels of VEGF, bFGF and Ang-1 before and after intervention and the clinical effect were compared between two groups. Results: There were no significant differences in baseline data, NIHSS score, MoCA score, serum levels of VEGF, bFGF and Ang-1 before intervention between the two groups (P>0.05). For intra-group comparison, the NIHSS score at 1 and 3 months after intervention of two groups were apparently lower than those before intervention, and MoCA score, serum levels of VEGF, bFGF and Ang-1 were apparently higher than those before intervention (P<0.05). For inter-group comparison, the NIHSS score in observation group at 1 and 3 months after intervention was apparently lower than that in control group, and the MoCA score, serum levels of VEGF, bFGF and Ang-1 were apparently higher than those in control group (P<0.05). The total efficacy of observation group at 3 months after intervention was apparently higher than that in control group (P<0.05). Conclusion: Clopidogrel combined with butylbenzene peptide could apparently improve the cognitive function of patients with ACI, elevate serum levels of vascular growth related factors such as VEGF, bFGF and Ang-1, whose clinical effect is significant and worthy of clinical application.
牛祥, 王本孝, 卜红伟. 氯吡格雷联合丁苯酞对急性脑梗死患者血清VEGF bFGF Ang-1水平及认知功能的影响[J]. 河北医学, 2022, 28(2): 318-322.
NIU Xiang, WANG Benxiao, BU Hongwei. Effect of Clopidogrel Combined with Butylbenzene Peptide on Serum Levels of VEGF bFGF Ang-1 and Cognitive Function in Patients with Acute Cerebral Infarction. HeBei Med, 2022, 28(2): 318-322.
2022, Vol. 28 
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