Effect of Coenzyme Q10 Combined with Sodium Fructose Diphosphate or Sodium Creatine Phosphate on Myocardial Enzyme Spectrum and Immune Function in Children with Viral Myocarditis
ZHANG Yaning, YUAN Zhanwang, GUO Yapeng
Women's and Children's Hospital, Shaanxi Xi'an710061,China
Abstract：Objective: To explore the effect of coenzyme Q10 combined with fructose sodium diphosphate or sodium phosphate in the treatment of myocardial spectrum and immune function of viral myocarditis. Methods: A total of 270 children with viral myocarditis admitted from November 2019 to November 2020 were selected as the subjects and divided into control group (142 cases, administered coenzyme Q10 fructose sodium diphosphate and sodium fructose diphosphate) and study group (128 cases, administered coenzyme Q10 fructose sodium diphosphate and sodium creatine phosphate). The therapeutic efficacy, myocardial enzyme spectrum (serum CK-MB、CPK、cTnI、HBDH、LDH) and immune function (CD3+、CD4+、CD4+/CD8+) were compared between the two groups. Results: The total effective rate of 1, 2 and 3 weeks treatment in the study group was higher than that in the control group, and the difference was statistically significant (Wald χ2 group =7.412, Wald χ2 time point =290.769, P group =0.006, P time point<0.001). Before treatment, there was no significant difference in the values of CK-MB, CPK, cTnI, HBDH, LDH, LVEF, FS, CI, CD3+, CD4+, CD4+/CD8+ between the two groups (P>0.05); After treatment, the levels of CK-MB, CPK, cTnI, HBDH and LDH in the study group were lower than those in the control group (P<0.05), LVEF, FS, CI, CD3+, CD4+, CD4+/CD8+ were higher than those in control group (P<0.05); The difference of CK-MB, CPK, cTnI, HBDH, LDH, LVEF, FS, CI, CD3+, CD4+, CD4+/CD8+ between the two groups before and after treatment was statistically significant (P<0.05).Conclusion: The effect of coenzyme Q10 combined with sodium phosphate in the treatment of viral myocarditis in children is better than that of coenzyme Q10 combined with sodium fructose diphosphate, which can effectively improve the myocardial enzyme spectrum and improve the immunity of children.
张雅宁, 袁展望, 郭亚鹏. 辅酶Q10联合果糖二磷酸钠或磷酸肌酸钠治疗小儿病毒性心肌炎对心肌酶谱及免疫功能的影响[J]. 河北医学, 2022, 28(1): 168-172.
ZHANG Yaning, YUAN Zhanwang, GUO Yapeng. Effect of Coenzyme Q10 Combined with Sodium Fructose Diphosphate or Sodium Creatine Phosphate on Myocardial Enzyme Spectrum and Immune Function in Children with Viral Myocarditis. HeBei Med, 2022, 28(1): 168-172.
[1] Chen J,Deng Y.Diagnostic performance of serum CK-MB,TNF-α and Hs-CRP in children with viral myocarditis[J].Open Life Sci,2019,20(14):38~42.[1] Othman HF,Byrnes J,Elsamny E,Hamzah M.Impact of ventricular arrhythmias on outcomes in children with myocarditis[J].Eur Pediatr,2020,179(11):1779~1786. [3] 马科,寇艳,卢蓉,等.磷酸肌酸钠治疗小儿病毒性心肌炎的疗效及对心肌酶和肌钙蛋白水平的影响[J].河北医学,2020,26(2):190~193. [4] 刘煜,任少琳,吴多新,等.磷酸肌酸钠联合辅酶Q10治疗小儿病毒性心肌炎效果分析[J].解放军预防医学杂志,2018,36(4):518~519. [5] 中华医学会儿科学分会心血管学组,中华儿科杂志编辑委员会.病毒性心肌炎诊断标准(修订草案)[J].中华儿科杂志,2000,38(2):75. [6] 郭宁,陈大兴,王杰,陶立轩,杨宇杰,刘艾.舒心通脉汤联合磷酸肌酸钠治疗病毒性心肌炎效果及对心肌功能指标的影响[J].中华中医药学刊,2020,38(5):190~193. [7] Lasrado N,Reddy J.An overview of the immune mechanisms of viral myocarditis[J].Rev Med Virol,2020,30(6):1~14. [8] 刘振球,蔡亲武,梁安珊.果糖二磷酸钠联合辅酶Q10片治疗小儿病毒性心肌炎疗效分析[J].心脑血管病防治,2020,20(3):305~307. [9] 蔡丽君,王晓丽,彭双勤.果糖二磷酸钠联合布拉氏酵母菌对轮状病毒肠炎患儿的疗效及心肌损伤的影响[J].中国临床研究,2020,33(11):1516~1519. [10] 姜红春.磷酸肌酸钠在小儿病毒性心肌炎治疗中的临床应用研究[J].湖南师范大学学报(医学版),2020,17(1):119~122. [11] 魏江,孙华.参麦注射液联合1,6-二磷酸果糖对病毒性心肌炎患儿心电图及心肌酶的影响[J].贵州医药,2019,43(10):1562~1563. [12] 李青华,张晓英,宋靖荣.磷酸肌酸钠对病毒性心肌炎患儿心功能及细胞免疫功能的影响[J].儿科药学杂志,2019,25(6):32~34.
2022, Vol. 28 
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