Abstract：Objective: To analyze the effect of platelet/lymphocyte ratio (PLR) on cognitive dysfunction in patients with cerebrovascular disease. Methods: 158 patients with cerebral small vessel disease in our hospital from January 2018 to January 2021 were retrospectively analyzed, according to whether the patients had cognitive impairment, and they were divided into a disorder group (n=67) and a control group (n =91). The general data and clinical data of the two groups were compared. Logistic multivariate analysis of the risk factors of cognitive dysfunction was conducted in patients with cerebral small vessel disease. Results: The levels of IMT, FBG, TC, TG, LDL, Hcy, hs-CRP and PLR in the disorder group were higher than those in the control group. The incidence of hyperhomocysteinemia, number of LI lesions, WMLS score and lacunar cerebrovascular disease in the disorder group were higher than those in the control group. Plasma HO-1 and albumin levels in the disorder group were lower than those in the control group, and the difference was statistically significant (P< 0.05). Logistic multivariate analysis showed that primary school education or below, number of LI lesions ≥5, WMLS score ≥10, IMT≥2mm, Hcy≥15μmol/L, PLR≥150, and plasma HO-1≤0.6μg/L were risk factors for cognitive dysfunction in patients with cerebral vascular disease (P< 0.05). PLR was positively correlated with the number of LI lesions, WMLS score, IMT and Hcy (P< 0.05), and negatively correlated with education level and plasma HO-1 (P< 0.05) in cerebrovascular disease patients. Conclusion: Education level, number of Li lesions, WMLs score, IMT, Hcy, PLR and plasma HO-1 levels were risk factors of cognitive impairment in patients with cerebral small vessel disease.
沈丽丽, 王学颖. 血小板/淋巴细胞比值对脑小血管病患者认知功能障碍的影响[J]. 河北医学, 2022, 28(1): 122-126.
SHEN Lili, WANG Xueying. Effect of Platelet/Lymphocyte Ratio on Cognitive Dysfunction in Patients with Cerebrovascular Disease. HeBei Med, 2022, 28(1): 122-126.
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2022, Vol. 28 
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