子痫前期孕妇血清STOX1 可溶性Fms样酪氨酸激酶-1水平及意义

doi:10.3969/j.issn.1006-6233.2022.01.012

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摘要 目的:研究子痫前期孕妇血清STOX1、可溶性Fms样酪氨酸激酶-1(sFlt-1)水平及意义。方法:选择本院2018年2月到2020年2月90例子痫前期孕妇作为研究对象,根据病情分为轻度组45例和重度组45例,另选择同期的40例健康孕妇作为对照组。比较三组的心率、血压[收缩压(SBP)和舒张压(DBP)]、平均动脉压(MAP)、脐动脉收缩末期峰值与舒张末期峰值比(S/D)、24h蛋白尿、血小板计数、谷丙转氨酶(ALT)、谷草转氨酶(AST)、血肌酐(Scr)、胎盘生长因子(PLGF)、STOX1、sFlt-1,并用Pearson相关性分析子痫前期孕妇血清STOX1、sFlt-1与各指标的关系。结果:对照组的心率、SBP、DBP、MAP、S/D、24h蛋白尿、ALT、AST、Scr、STOX1、sFlt-1显著低于轻度组和重度组,轻度组的心率、SBP、DBP、MAP、S/D、24h蛋白尿、ALT、AST、Scr、STOX1、sFlt-1显著低于重度组;对照组的血小板计数、PLGF显著高于轻度组和重度组,轻度组的血小板计数、PLGF显著高于重度组,差异均有统计学意义(P<0.05)。经Pearson相关性分析,STOX1与心率、SBP、DBP、MAP、S/D、24h蛋白尿均呈正相关(P<0.05),与PLGF呈负相关(P<0.05),与血小板计数、ALT、AST、Scr均无相关性(P>0.05);sFlt-1与心率、SBP、DBP、MAP、S/D、24h蛋白尿均呈正相关(P<0.05),与PLGF呈负相关(P<0.05),与血小板计数、ALT、AST、Scr均无相关性(P>0.05)。结论:子痫前期孕妇血清STOX1、sFlt-1水平随病情进展而升高,临床可结合SBP、DBP、MAP、24h蛋白尿、PLGF的变化,对孕妇的病情进行预测和控制,以延长孕周或及时终止妊娠。

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关键词 ：子痫前期, STOX1, 可溶性Fms样酪氨酸激酶-1, 血压, 平均动脉压, 24h蛋白尿

Abstract：Objective: To study the level and significance of Serum STOX1 and soluble Fms-like tyrosine kinase-1 (sFlt-1) in pregnant women with preeclampsia. Methods: Ninety pre-eclampsia pregnant women admitted to our hospital from February 2018 to February 2020 were selected as the research subjects. They were divided into 45 cases in mild group and 45 cases in severe group according to the condition, and 40 healthy pregnant women in the same period were selected as control group. Heart rate, blood pressure [systolic blood pressure (SBP) and diastolic blood pressure (DBP)], mean arterial pressure (MAP), ratio of umbilical artery peak systolic to peak diastolic peak (S/D), 24h proteinuria, platelet count, alanine aminotransferase (ALT), aspartate aminotransferase (AST), blood creatinine (Scr), placental growth factor (PLGF), STOX1 and sFlt-1 were compared among the three groups. Pearson correlation was used to analyze the relationship between serum STOX1 and sFlt-1 in preeclamptic women. Results: The heart rate, SBP, DBP, MAP, S/D, 24h proteinuria, ALT, AST, Scr, STOX1, sFlt-1 of the control group were significantly lower than those of the mild and severe groups. The heart rate, SBP, DBP, MAP, S/D, 24h proteinuria, ALT, AST, Scr, STOX1, sFlt-1 were significantly lower than the severe group; the platelet count and PLGF of the control group were significantly higher than those of the mild and severe groups. The platelet count and PLGF of the mild group were significantly higher than the severe group, the differences were statistically significant (P<0.05). By Pearson's correlation analysis, STOX1 was positively correlated with heart rate, SBP, DBP, MAP, S/D, and 24h proteinuria (P<0.05), negatively correlated with PLGF (P<0.05), and not correlated with platelet count, ALT, AST or Scr (P>0.05). sFlt-1 was positively correlated with heart rate, SBP, DBP, MAP, S/D, and 24h proteinuria (P<0.05), negatively correlated with PLGF (P<0.05), and not correlated with platelet count, ALT, AST, or Scr (P>0.05). Conclusion: The serum STOX1, sFlt-1 levels of preeclampsia pregnant women increase with the progression of the disease. Clinically, the changes of SBP, DBP, MAP, 24h proteinuria, and PLGF can be combined to predict and control the condition of pregnant women to prolong the gestational week Termination of pregnancy.

Key words： Preeclampsia STOX1 SFlt-1 Blood pressure MAP 24h Proteinuria

基金资助:2016年承德市科学技术研究与发展计划项目,(编号:201606A033)

通讯作者: 葛永梅

引用本文:

朱艳菊, 肖艳平, 付久园, 郭艳巍, 葛永梅. 子痫前期孕妇血清STOX1 可溶性Fms样酪氨酸激酶-1水平及意义[J]. 河北医学, 2022, 28(1): 57-60.
ZHU Yanju, XIAO Yanping, FU Jiuyuan, et al. Level and Significance of Serum STOX1 and Soluble Fms-Like Tyrosine Kinase-1 in Pregnant Women with Preeclampsia. HeBei Med, 2022, 28(1): 57-60.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2022.01.012 或 http://www.hbyxzzs.cn/CN/Y2022/V28/I1/57

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