Effect of Ergometrine Combined with Carboprost Aminobutyric Triol on Preventing Postpartum Hemorrhage in Patients with Scar Uterus after Cesarean Section and Its Effect on GSH Px SOD MDA and Postpartum Lactation
QIU Qian, YAO Ronghua, HUANG Junjie, et al
Joint Logistics Support Force 901 Hospital, Anhui Hefei 230031, China
Abstract：Objective: To investigate the effect of the combination of Ergometrine and Carboprost Tromethamine Injection in preventing postpartum hemorrhage in patients with scarred uterus re-cesarean section and its influence on glutathione peroxidase (GSH-px), superoxide dismutase (SOD), malondialdehyde (MDA) and postpartum lactation. Methods: A total of 92 patients with scarred uterus re-cesarean section in our hospital from February 2018 to April 2020 were selected as the research objects. They were divided into observation group and control group by simple randomization method, with 46 cases in each group. The control group was treated with Carboprost Tromethamine Injection to prevent postpartum hemorrhage, and the observation group was treated with Ergometrine combined with Carboprost Tromethamine Injection to prevent postpartum hemorrhage. The efficacy, postpartum hemorrhage, recovery, lactation, and adverse reactions, coagulation function indexes [activated partial thromboplastin time (APTT), prothrombin time (PT), fibrinogen (FIB), D-dimer (DD)], serum GSH-px, SOD, MDA levels before and 24 hours after the operation of the two groups were compared. Results: After treatment, the total effective rate of the observation group was 93.48% higher than that of the control group 76.09% (P<0.05). The bleeding volume and rate of postpartum hemorrhage at 2 h and 24 h in the observation group were lower than those in the control group, the duration of lochia and hospital stay were shorter than those in the control group, and the uterine fundus declined faster than the control group (P<0.05). The levels of APTT, PT, FIB, DD, and serum MDA in the two groups at 24 h after surgery were lower than those before the operation, and the observation group was lower than the control group, and the serum GSH-px and SOD levels were higher than those before operation, and the observation group was higher than the control group (P<0.05). The lactation initiation time of the observation group was shorter than that of the control group, and the lactation volume scores of the 1 and 2 d postpartum were higher than those of the control group (P<0.05); there was no significant difference in the incidence of adverse reactions between the two groups (P>0.05). Conclusion: The combined application of Ergometrine and Carboprost Tromethamine Injection to prevent postpartum hemorrhage in patients with scarred uterus re-cesarean section can significantly improve the preventive effect, reduce postpartum hemorrhage, and promote the recovery of patients, improve coagulation function and lactation, reduce serum GSH-px, SOD, MDA levels, reduce oxidative stress, and have good safety.
仇茜, 姚荣华, 黄俊杰, 俞敏. 麦角新碱与卡前列素氨丁三醇联合预防瘢痕子宫再次剖宫产患者产后出血的效果及对GSH-px SOD MDA 产后泌乳情况的影响[J]. 河北医学, 2021, 27(11): 1901-1907.
QIU Qian, YAO Ronghua, HUANG Junjie, et al. Effect of Ergometrine Combined with Carboprost Aminobutyric Triol on Preventing Postpartum Hemorrhage in Patients with Scar Uterus after Cesarean Section and Its Effect on GSH Px SOD MDA and Postpartum Lactation. HeBei Med, 2021, 27(11): 1901-1907.
2021, Vol. 27 
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