[1] Fakhoury Marc,et al.Microglia and astrocytes in alzheimer's disease:implications for therapy[J] .Curr Neuropharmacol,2018,16(5):508~518. [2] Ma Kun,Guo Jingjing,Wang Guan,et al.Toll-like receptor 2-mediated autophagy promotes microglial cell death by modulating the microglial M1/M2 phenotype[J] .Inflammation,2020,43(2):701~711. [3] Ravari Ali,Mirzaei Tayebeh,Kennedy Derek,et al.Chronoinflammaging in alzheimer; a systematic review on the roles of toll like receptor 2[J].Life Sciences,2017,171(1):16~20. [4] Momtazmanesh Sara,Perry George,Rezaei Nima,et al.Toll-like receptors in alzheimer's disease[J] .Neuroimmunol,2020,348:577362. [5] Chakrabarty,P.,et al.TLR5 decoy receptor as a novel anti-amyloid therapeutic for alzheimer’s disease[J] .Exp Med,2018,215(9):2247~2264. [6] Chen Si-Han,Tian Ding-Yuan,Shen Ying-Ying,et al.Amyloid-beta uptake by blood monocytes is reduced with ageing and alzheimer's disease[J] .Transl Psychiatry,2020,10(1):423. [7] Zhou,C.,et al.Genomic deletion of TLR2 induces aggravated white matter damage and deteriorated neurobehavioral functions in mouse models of Alzheimer's disease[J].Aging (Albany NY),2019,11(17):7257~7273. [8] Xiang,W.,et al.Role of toll-like receptor/MYD88 signaling in neurodegenerative diseases[J].Rev.Neurosci,2015,26(4):407~414. [9] Dallas Mark L,Widera Darius,et al.TLR2 and TLR4-mediated inflammation in alzheimer's disease:self-defense or sabotage[J].Neural Regen Res,2021,16(8):1552~1553. [10] Rubio-Araiz,A.,et al.Anti-TLR2 antibody triggers oxidative phosphorylation in microglia and increases phagocytosis of beta- amyloid[J].Neuroinflammation,2018,15(1):247. [11] Pourbadie Hamid Gholami,Sayyah Mohammad,et al.Early minor stimulation of microglial TLR2 and TLR4 receptors attenuates alzheimer's disease-related cognitive deficit in rats:behavioral,molecular,and electrophysiological evidence[J] .Neurobiol Aging,2018,70(6):203~216. [12] Heshmati-Fakhr Nooshin,Sotoodehnejadnematalahi Fattah,et al.Triggering microglia through toll-like receptor 2 pathway induced interferon β expression in cell and animal model of Alzheimer's disease[J] .Neuroreport,2018,29(17):1456~1462. [13] McDonald,C.L.,Hennessy,E.,et al.Inhibiting TLR2 activation attenuates amyloid accumulation and glial activation in a mouse model of Alzheimer’s disease[J].Brain Behav Immun,2016,58(7):191~200. [14] 狄婷婷,张美,王瑞婷,等.Toll样受体-2、核因子-κB在Aβ诱导的阿尔茨海默病中的作用[J].中国老年学杂志,2016,36(23):5780~5782. [15] Garcez,M.L.,Mina,F.,et al.The involvement of NLRP3 on the effects of minocycline in an AD-like pathology induced by beta-amyloid oligomers administered to mice[J].Mol.Neurobiol,2019,56(4):2606~2617. [16] Qi Yue,Ji Xue-Fei,et al.Xanthoceraside attenuates amyloid β peptide-induced memory impairments by reducing neuroinflammatory responses in mice[J] .Eur Pharmacol,2018,820(11):18~30. [17] Mehrabadi Shima,Motevaseli Elahe,Sadr Seyed Shahabeddin,et al.Hypoxic-conditioned medium from adipose tissue mesenchymal stem cells improved neuroinflammation through alternation of toll like receptor (TLR) 2 and TLR4 expression in model of Alzheimer's disease rats[J] .Behav Brain Res,2020,379:112362.