Effect of Butylphthalide Soft Capsules Combined with Dual Antiplatelet Therapy in the Treatment of Acute Ischemic Stroke and the Influence on Serum β2-MG HCY CysC and Neurological Function
ZHU Jin, DU Yuping
No.904 Hospital, Joint Logistics Support Force of Chinese people's Liberation Army, Jiangsu Wuxi 214037, China
Abstract：Objective: To investigate the effect of butylphthalide soft capsules combined with dual antiplatelet therapy in the treatment of acute ischemic stroke and the influence on serum β2-microglobulin (β2-MG), homocysteine (HCY), cystatin C (CysC) and neurological function. Methods: From January 2017 to December 2019, 157 patients with acute ischemic stroke were selected and simple randomly divided into combined group (77 cases) and control group (80 cases). Both groups were treated with aspirin and clopidogrel after thrombolysis. On this basis, the combined group were treated with butylphthalide soft capsules. A month later, the clinical effect was evaluated, and serum β2-MG, HCY and CysC levels were measured. The National Institutes of Health Stroke Scale (NIHSS) scores and Barthel index were used to evaluate. Results: After 1 month of treatment, the total response rate in the combined group was 93.51%, higher than 81.25% in the control group (P<0.05). The difference before and after treatment of serum β2-MG, HCY and CysC in the combined group were higher than those in the control group (P<0.05). The combined group had lower NIHSS scores and higher Barthel index than the control group (P<0.05). The incidences of adverse reactions in the two groups were 10.39% and 12.50%, respectively (P>0.05). Conclusion: On the basis of conventional dual antiplatelet therapy for acute ischemic stroke, combined use of butylphthalide soft capsules can significantly improve the curative effect and stroke-related biochemical indicators, and promote neurological function recovery, thereby increase clinical benefits.
朱金, 杜宇平. 丁苯酞软胶囊联合双联抗血小板治疗急性缺血性脑卒中疗效及对血清β2-MG HCY CysC和神经功能的影响[J]. 河北医学, 2021, 27(10): 1734-1738.
ZHU Jin, DU Yuping. Effect of Butylphthalide Soft Capsules Combined with Dual Antiplatelet Therapy in the Treatment of Acute Ischemic Stroke and the Influence on Serum β2-MG HCY CysC and Neurological Function. HeBei Med, 2021, 27(10): 1734-1738.
[1] 中国老年医学学会急诊医学分会,中华医学会急诊医学分会卒中学组,中国卒中学会急救医学分会.急性缺血性脑卒中急诊急救中国专家共识2018[J].中国卒中杂志,2018,13(9):956~967. [2] Stringberg A,Camden R,Qualls K,et al.Update on dual antiplatelet therapy for secondary stroke prevention[J].Mo Med,2019,116(4):303~307. [3] 郭灶耿,黄俊尹,孟瑞伟,等.深圳市≥40岁社区居民高同型半胱氨酸的患病情况及其与脑卒中患病风险的相关性[J].中华健康管理学杂志,2021,15(1):37~43. [4] 李健,饶源,张岐平.丁苯酞软胶囊对缺血性脑血管病的疗效及对血清ox-LDL,Lp-PLA2,炎症因子水平的影响[J].解放军预防医学杂志,2018,205(4):27~29. [5] 彭斌,吴波.中国急性缺血性脑卒中诊治指南2018[J].中华神经科杂志,2018,51(9):666~682. [6] Wirtz MM,Hendrix P,Goren O,et al.Predictor of 90-day functional outcome after mechanical thrombectomy for large vessel occlusion stroke:NIHSS score of 10 or less at 24 hours[J].Neurosurg,2019,12(20):1~7. [7] Silva GS,Nogueira RG.Endovascular treatment of acute ischemic stroke[J].Continuum (Minneap Minn),2020,26(2):310~331. [8] Lee SY,Kim DY,Sohn MK,et al.Determining the cut-off score for the modified barthel index and the modified rankin scale for assessment of functional independence and residual disability after stroke[J].PLoS One,2020,15(1):226~324. [9] 于兰兰,刘飞,赵素芹,等.丁苯酞联合双抗血小板治疗对急性分水岭脑梗死近期神经功能,日常生活能力的影响[J].河北医药,2020,42(10):72~75. [10] Zhang L,Sun J,Zhang M,et al.The significance of combined detection of CysC,urinary mAlb and β2-MG in diagnosis of the early renal injury in pregnancy-induced hypertension syndrome[J].Saudi Biol Sci,2019,26(8):1982~1985. [11] Raffield LM,Ellis J,Olson NC,et al.Genome-wide association study of homocysteine in african americans from the jackson heart study,the multi-ethnic study of atherosclerosis,and the coronary artery risk in young adults study[J].Hum Genet,2018,63(3):327~337. [12] 呼格吉乐,丛殿宝,张建辉,等.阿司匹林+氯吡格雷双联抗血小板聚集联合丁苯酞治疗高龄急性大脑中动脉缺血性脑卒中的疗效[J].中国老年学杂志,2019,39(21):5183~5186. [13] Wo X,Han J,Wang J,et al.Sequential butylphthalide therapy combined with dual antiplatelet therapy in the treatment of acute cerebral infarction[J].Pak Med Sci,2020,36(4):615~620. [14] 黄优,陈海云,何超明,等.丁苯酞软胶囊对颈动脉狭窄大鼠大脑缺血再灌注后Smac蛋白的影响[J].实用药物与临床,2020,23(2):20~23.
2021, Vol. 27 
冀公网安备13080202000677号