Abstract：Objective: To analyze the correlation between serum homocysteine (Hcy), N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels and arrhythmia in patients with chronic heart failure (CHF), aiming to further investigate the pathological mechanism of arrhythmia in patients with CHF, and to provide a basis for early clinical detection and development of treatment plans. Methods: The medical data of 76 CHF patients were retrospectively analyzed. According to whether there was arrhythmia or not, 45 patients without arrhythmia were included in the non-arrhythmia group, and 31 patients with arrhythmia were included in the arrhythmia group. Another 30 healthy people who were admitted to the hospital for physical examination during the same period were selected as the control group. The general data, blood lipid, serum creatinine (Cr), serum Hcy and NT-proBNP levels of the subjects were carefully recorded. The Pearson method was used to test the correlation between serum Hcy and NT-proBNP. The general linear regression analysis was used to obtain the linear regression equation to test the effect of serum Hcy and NT-proBNP levels on the occurrence of arrhythmia in patients with CHF. The area under the curve was obtained by plotting the ROC curve, and the value of serum Hcy and NT-proBNP levels in the prediction of arrhythmia in patients with CHF was tested. Results: The levels of serum Hcy and NT-proBNP in the arrhythmia group were higher than those in the non-arrhythmia group and the control group, with a statistical significant difference (P<0.05); the levels of serum Hcy and NT-proBNP in the non-arrhythmia group were higher than those in the control group, with a statistical significant difference (P<0.05); the bivariate Pearson correlation test showed that serum Hcy was positively correlated with NT-proBNP in CHF patients with arrhythmia (r=0.371, P<0.001); the linear regression equation was obtained by linear regression analysis: Y (Hcy)=0.717+0.063X, Y (NT-proBNP)=1.016+0.002X, and serum Hcy and NT-proBNP may be the influencing factors for inducing arrhythmia in patients with CHF (P<0.05); the arrhythmia in CHF patients was used as a state variable, and the ROC curve was plotted, and the results showed that the areas under the curve of serum Hcy and NT-proBN levels in predicting the occurrence of arrhythmia in CHF patients were 0.857 (95%CI: 0.775-0.939) and 0.913 (95%CI: 0.860-0.965), the sensitivity was 86.71% and 90.00%, and the specificity was 68.45%, 71.10%, respectively. Conclusion: Serum Hcy and NT-proBNP levels are closely related to arrhythmia in patients with CHF, which may be the influencing factors for arrhythmia in patients with CHF. Clinical evaluation of serum Hcy and NT-proBNP levels in patients with CHF has higher application value in predicting the occurrence of arrhythmia.
孟成, 吕磊, 周跟东. 血清Hcy NT-proBNP水平与慢性心力衰竭患者心律失常的相关性[J]. 河北医学, 2021, 27(10): 1687-1691.
MENG Cheng, LV Lei, et al. An Analysis of the Correlation Between Serum Hcy NT-ProBNP Levels and Arrhythmia in Patients with Chronic Heart Failure. HeBei Med, 2021, 27(10): 1687-1691.
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2021, Vol. 27 
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