Abstract：Objective: To investigate the diagnostic value of peritoneal dialysis (PD) drainage fluid interleukin-6 (IL-6) and neutrophil gelatinase-associated lipocalin (NGAL) in peritoneal dialysis-associated peritonitis (PDAP). Methods: A total of 120 patients hospitalized in the nephrology department and undergoing PD in the hospital between January 2019 and September 2020 were selected as study objects. According to the presence or absence of PDAP, the patients were divided into PDAP group and non-PDAP group. The levels of drainage fluid IL-6 and NGAL in the two groups were compared, and their diagnostic valuein PDAP was analyzed. Results: Follow-up revealed that 55 of the 120 patients developed PDAP. The drainage fluid IL-6, NGAL and WBC, and dialysis age of the PDAP group were significantly higher or longer than those of the non-PDAP group (P<0.05). Drainage fluid IL-6, NGAL and WBC, and dialysis age were independent risk factors for PDAP. Both IL-6 and NGAL single detection were of high value in the diagnosis of PDAP. Conclusion: IL-6 and NGAL in drainage fluid are independent risk factors for PDAP, which provides an effective basis for the diagnosis of PDAP.
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2021, Vol. 27 
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