Abstract：Objective: To investigate the expression and clinical significance of gene of phosphate and tension homology deleted on chromosome ten (PTEN) and Notch receptor 1 (Notch1) in non-small cell lung cancer (NSCLC) tissues. Methods: 67 cases of cancer tissue specimens from NSCLC patients in our hospital from January 2016 to December 2017 were collected. At the same time, twenty-five cases of lung tissue specimens confirmed by histopathology were selected as the control group. Immunohistochemical method was used to detect the expression of PTEN and Notch1 in NSCLC tissues, and to analyze the relationship between the two and the clinical data of NSCLC patients. The patients with NSCLC were followed up for 36 months. Kendall's tau-b method was used to analyze the correlation between PTEN and Notch1 in NSCLC tissues; Kaplan-Meier survival curve was used to analyze the relationship between PTEN, Notch1 and the prognosis of NSCLC patients; COX regression was used to analyze the factors affecting the prognosis of NSCLC patients. Results: Compared with normal lung tissue, the positive expression of PTEN in NSCLC tissue was significantly reduced, and the positive expression rate of Notch1 was significantly increased, the difference was statistically significant (P<0.05). Compared with NSCLC patients without lymph node metastasis and with TNM stage I+II, NSCLC patients with lymph node metastasis and TNM stage III had a significantly lower the positive expression rate of PTEN, and a significantly higher positive expression rate of Notch1, the difference was statistically significant (P<0.05). The expression of PTEN and Notch1 in NSCLC tissue was negatively correlated (r=-0.356, P<0.05). The cumulative survival rate of patients in the PTEN positive expression group (63.0%) was higher than that in the negative expression group (44.6%); the cumulative survival rate of patients in the Notch1 positive expression group (43.1%) was lower than that in the negative expression group (63.0%). Multivariate COX analysis showed that TNM staging, positive expression of Notch1, and negative expression of PTEN were risk factors affecting the prognosis of NSCLC patients (P<0.05). Conclusion: The expression of PTEN and Notch1 in NSCLC tissues and normal lung tissues are significantly different, they are related to lymph node metastasis and TNM staging in NSCLC patients, and may be important factors in the occurrence and development of NSCLC.
张媛媛, 马静, 何会娜, 郭银, 李香兰, 池菲. PTEN和Notch1在非小细胞肺癌组织中表达及临床意义[J]. 河北医学, 2021, 27(10): 1637-1642.
ZHANG Yuanyuan, MA Jing, HE Huina, et al. Expression and the Clinical Significance of PTEN and Notch1 in Non-small cell Lung Cancer. HeBei Med, 2021, 27(10): 1637-1642.
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2021, Vol. 27 
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