Abstract：Objective: To analyze the treatment effect of self-made Bushen Tiaojing decoction on polycystic ovary syndrome (PCOS). Methods: A total of 140 patients with PCOS (kidney deficiency and phlegm stasis syndrome) who came to our hospital between March 2018 and February 2020 were selected as the research subjects, and they were randomly divided into observation group and control group according to the random number table method, with 70 cases in each group. Control group was given ethinylestradiol and cyproterone acetate tablets and conventional western medicine treatment, and observation group was given Jiawei self-made Bushen Tiaojing decoction on the basis of control group. The TCM syndromes scores, uterine-related indexes [endometrial thickness, ovarian volume, cervical mucus score (Insler cervical scoring method)], serum related factors [serum anti-Mullerian hormone (AMH), luteinizing hormone (LH), follicle stimulating hormone (FSH)] and occurrence of adverse reactions were compared between the two groups of patients before treatment and at 6 months of treatment. The ovulation rate and natural pregnancy rate were recorded in the two groups of patients during 1-year follow-up. Results: The scores of symptoms of irregular menstruation, soreness and weakness of waist and knees, fatigue, abnormal leukorrhea and dysmenorrhea in the two groups of patients after 6 months of treatment were significantly lower than those before treatment, and the scores of observation group were significantly lower than those of control group (all P<0.05). And the differences of symptoms scores before and after treatment in observation group were significantly higher than those in control group (all P<0.05). The endometrial thickness and cervical mucus score of the two groups of patients at 6 months of treatment were significantly increased compared with those before treatment while the ovarian volume was significantly decreased compared with that before treatment, and there were statistically significant differences between observation group and control group (all P<0.05), and the differences of indicators changes before and after treatment were significantly different between the two groups (all P<0.05). At 6 months of treatment, the levels of serum AMH, LH and FSH of the two groups were significantly reduced compared with those before treatment, and the levels of AMH and LH in observation group were significantly lower than those in control group (all P<0.05). There was no significant difference in FSH level between the two groups (P>0.05), and there were statistical significance in the differences of indicators before and after treatment between the two groups (all P<0.05). There were no significant differences in the occurrence of adverse reactions such as dizziness, nausea and mild abdominal pain between the two groups of patients during treatment (P>0.05). At 1-year follow-up, the ovulation rate and natural pregnancy rate of observation group were significantly higher than those of control group (all P<0.05). Conclusion: Jiawei Bushen Tiaojing decoction in the treatment of PCOS (kidney deficiency and phlegm stasis syndrome) can effectively improve the symptoms of irregular menstruation and fatigue as well as ovarian function, and it is conducive to smooth ovulation and promotion of natural pregnancy. It has a definite efficacy and good safety.
周丽娜, 辛欢, 杨敏. 自拟补肾调经方加味治疗多囊卵巢综合征效果及血清AMH LH和FSH水平的影响[J]. 河北医学, 2021, 27(9): 1572-1577.
ZHOU Lina, XIN Huan, YANG Min. Effect of Jiawei Self-made Bushen Tiaojing Decoction on Polycystic Ovary Syndrome and Its Influence on Levels of Serum AMH LH and FSH. HeBei Med, 2021, 27(9): 1572-1577.
2021, Vol. 27 
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