Abstract：Objective: To analyze the diagnostic value of three-dimensional color Doppler flow imaging (CDFI) combined with serum creatine kinase (CK) and human chorionic gonadotropin (HCG) in prenatal placental implantation. Methods: 195 pregnant women with high risk factors of placental implantation and underwent cesarean section in the Affiliated Hospital of Chengde Medical University from 2015 to 2017 were selected as the study objects. According to the pathological diagnosis results of placenta after delivery, pregnant women were divided into placental implantation group (n = 86) and non fetal disc implantation group (n = 109). CK and HCG in serum were detected by automatic biochemical analyzer; CDFI was used to analyze the placental implantation of the two groups; the gold standard was the pathological diagnosis of placenta after delivery, and the diagnostic values of serum CK, CHG and CDFI single and combined diagnoses in prenatal placental implantation were analyzed. Results: The levels of serum CK and HCG in placenta group were higher than those in non placenta group (P<0.05). The results of CDFI showed that the rates of characteristic appearance such as fuzzy boundary between placenta and myometrium, placental parenchymal lacunar blood flow signal, placenta highly vascularized, dark area of irregular fluid property in placenta, and bladder protuberance of pregnant women in placenta implantation group were significantly higher than those in non placenta implantation group (P<0.05). The sensitivities of serum CK, CHG and CDFI single diagnoses were 46.51%, 48.84% and 67.44% respectively, and the specificities were 82.41%, 80.66% and 83.07% respectively. The sensitivity and specificity of CDF1 combined with CK and CHG were 94.85% and 87.62% respectively. Conclusions: Detection of DFI combined with serum CK and HCG can improve the sensitivity and accuracy of prenatal placental implantation diagnosis, which has the potential to become the diagnostic standard of prenatal placental implantation.
周冰峰, 阚长利, 郭艳巍, 侯敬. 彩色多普勒超声联合检测血清CK HCG水平对胎盘植入的诊断价值[J]. 河北医学, 2021, 27(9): 1535-1539.
ZHOU Bingfeng, KAN Changli, GUO Yanwei, et al. Diagnostic Value of Color Doppler Ultrasound Combined with Serum Creatine Kinase and HCG in Placental Implantation. HeBei Med, 2021, 27(9): 1535-1539.
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2021, Vol. 27 
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