Abstract：Objective: To analyze the effects of hemodialysis combined with hemoperfusion on oxidative stress markers and islet function in patients with diabetic end-stage renal disease (DN-ESRD). Methods: Totally 80 patients with diabetic end-stage renal disease were randomly divided into two groups. 40 patients with HD were made the study group, and 40 patients with HD combined with HP were selected as the control group. The renal function markers [blood creatinine (SCr), urea nitrogen (BUN) and cystic filtration rate (GFR)], oxidative stress markers [reactive oxygen species (ROS), superoxide dismigase (SOD), propylene duedehyde (MDA)] were measured by ELISA Kit before and after treatment in the two groups. The islet function related indicators [insulin resistance index (HOMA - β), insulin resistance index (HOMA-IR) and insulin sensitivity index (ISI)] were calculated by homeostasis model. Results: Before treatment, there was no differences in renal function markers, oxidative stress markers, and islet function between groups (P>0.05). After treatment, the SCr, BUN, ROS, MDA and HOMA-IR levels were reduced in both groups, the GFR, SOD, HOMA-β and ISI levels were increased in both groups, and the change of the study group was higher than the control group, with statistically significant differences (P<0.05). Conclusion: Hemodialysis combined blood irrigation play a better role in reducing oxidative stress damage and improving islet function than hemodialysis alone, which is more effective in improving patients' kidney function.
秦盼盼, 陈朝娟. 血液透析联合血液灌流对糖尿病终末期肾病患者氧化应激和胰岛功能的影响[J]. 河北医学, 2021, 27(9): 1531-1534.
QIN Panpan, CHEN Chaojuan. Effect of Hemodialysis Combined with Hemoperfusion on Oxidative Stress and Islet Function in Patients with DN-ESRD. HeBei Med, 2021, 27(9): 1531-1534.
[1] 张艳秋,程项阳.血液灌流串联血液透析治疗对终末期糖尿病肾病患者微炎症及营养状态的影响[J].透析与人工器官,2020,9(31):18~20. [2] 廖锋群.血液灌流联合透析对终末期糖尿病肾病患者胰岛素抵抗与营养状态的影响[J].医药论坛杂志,2020,9( 41):77-80. [3] 中华医学会糖尿病学分会微血管并发症学组.糖尿病肾病防治专家共识(2014年版) [J].中华糖尿病杂志,2014,6(11):792~801. [4] Wang F,Yang C,Long J,et al.Executive summary for the 2015 annual data report of the China kidney disease network (CK-NET) [J].Kidney Int,2019,95(3):501~505. [5] 程建萍,陈玉平,黄力,等.血液透析联合血液灌流对终末期糖尿病肾病患者的预后研究[J].临床医药文献电子杂志,2018,18( 4):234~239. [6] Agbas A,Canpolat N,Caliskan S,et al.Hemodiafiltration is associated with reduced inflammation,oxidative stress and improved endothelial risk profile compared to high-flux hemodialysis in children [J].PLoS One,2018,13(6):e0198320. [7] 郑长新,徐文珠,连景铃,等.血液透析联合血液灌流在糖尿病肾病患者中的应用效果[J].糖尿病新世界,2020,9(1):169~170. [8] 岳萌,孙世辉,张紫晶,等.活性氧通过影响线粒体膜电位参与小鼠高血糖加重脑缺血性损伤[J].神经解剖学杂志,2019,35( 1):35~40.
2021, Vol. 27 
冀公网安备13080202000677号