An Observation of the Therapeutic Effect of Repeated Transcranial MagneticStimulation Guided by Event-Related Potentials on Children with Autism Spectrum Disorder
JIAN Jie, et al
The Fifth Affiliated Hospital of Zhengzhou University, Henan Zhengzhou 450052, China
Abstract：Objective: To analyze the clinical efficacy of high-low frequency repetitive transcranial magnetic stimulation (rTMS) under the guidance of event-related potential (ERP) combined with comprehensive rehabilitation training in the treatment of children with autism spectrum disorder (ASD). Methods: 60 ASD children who visited the fifth affiliated hospital of Zhengzhou University from January 2018 to February 2019 were selected and randomly divided into the experimental group (n=30) and the control group (n=30). Both the two groups received comprehensive rehabilitation treatment. On this basis, the control group were treated with conventional rTMS treatment, while the experimental group were treated with high-frequency and low-frequency rTMS treatment in the abnormal brain areas according to the guidance of ERP. The children’s autism rating scale (CARS), autistic children’s behavior checklist (ABC), and autism treatment evaluation scale (ATEC) were used to compare the efficacy of the two groups after treatment. Results: Before treatment, there were no significant differences in CARS, ABC and ATEC scores between the two groups(P>0.05). After 3 months of treatment, the CARS score of the experimental group (34.63±1.94) was significantly lower than that of the control group (35.73±1.96, P<0.05), the total score of ABC (50.10±4.55) was significantly lower than that of control group(54.53±5.43, P<0.05), and the ATEC score (53.53±4.70) was significantly lower than that of the control group (59.07±5.95, P<0.05). After 6 months of treatment, the CARS score of the experimental group (33.87±2.49) was significantly lower than that of the control group (31.50±2.05, P<0.05), the total score of ABC (50.00±5.13) was significantly lower than that of control group (40.01±4.86, P<0.05), and the ATEC score (47.00±5.08) was significantly lower than that of the control group (54.93±6.70, P<0.05). Conclusion: The rTMS treatment plan under the guidance of ERP has a more significant improvement effect in the treatment of ASD than the conventional rTMS, which can provide a certain reference for the treatment of children with ASD by rTMS.
简婕, 刘智慧, 李立国, 孙榛誉, 赵鹏举, 李恩耀. 事件相关电位指导下重复经颅磁刺激治疗孤独症儿童的疗效观察[J]. 河北医学, 2021, 27(9): 1512-1516.
JIAN Jie, et al. An Observation of the Therapeutic Effect of Repeated Transcranial MagneticStimulation Guided by Event-Related Potentials on Children with Autism Spectrum Disorder. HeBei Med, 2021, 27(9): 1512-1516.
[1] 谭成慧,宋博海,马姗姗,等.自闭症患儿行为干预研究方法的发展与趋势[J].中国临床心理学杂志,2021,29(2):436~442. [2] 陆如蓝,张成亮,周先举.重复经颅磁刺激治疗焦虑相关障碍 研究进展[J].中国神经精神疾病杂志,2018,44(9):570~573. [3] 吴桂森,甘冉飘,唐晓晨,等.事件相关电位对精神病临床高危人群临床结局的预测作用[J].中华行为医学与脑科学杂志,2020,29(4):379~384. [4] 李海,黄东锋.事件相关电位在自闭症谱系障碍神经电生理研究中的进展[J].中国康复,2016,31(5):390. [5] Mahapatra S,Vyshedsky D,Martinez S,et al.Autism treatment evaluation checklist (ATEC) norms:a "growth chart" for ATEC score changes as a function of age[J].Children (Basel),2018,5(2):25. [6] 胡春维,魏玉珊,孙艳萍,等.综合康复训练对孤独症儿童康复效果分析[J].神经损伤与功能重建,2015,(2):131~133. [7] Ameis SH,Blumberger DM,Croarkin PE,et al.Treatment of executive function deficits in autism spectrum disorder with repetitive transcranial magnetic stimulation:a double-blind,sham-controlled,pilot trial[J].Brain Stimul,2020,13(3):539~547. [8] Sokhadze EM,Lamina EV,Casanova EL,et al.Exploratory study of rTMS neuromodulation effects on electrocortical functional measures of performance in an oddball test and behavioral symptoms in autism[J].Front Syst Neurosci,2018,12:20. [9] Enticott PG,Fitzgibbon BM,Kennedy HA,et al.A double-blind,randomized trial of deep repetitive transcranial magnetic stimulation (rTMS) for autism spectrum disorder[J].Brain Stimul,2014,7(2):206~211. [10] Sheela P,Puthankattil SD.Event related potential analysis techniques for autism spectrum disorders:A review[J].Int Dev Neurosci,2018,68:72~82.
2021, Vol. 27 
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