CT Perfusion Imaging Evaluates the Curative Effect of NP Chemotherapy Combined with Brucea Javanica Oil Emulsion in the Treatment of Non-Small Cell Lung Cancer
LI Chuangui, LIU Xiaocheng, ZHANG Xinhui, et al
The First Affiliated Hospital of Hebei North University, Hebei Zhangjiakou 075000, China
Abstract：Objective: To evaluate the clinical application value of NP chemotherapy combined with Brucea javanica oil emulsion in the treatment of non-small cell lung cancer using CT perfusion imaging technology. Methods: The imaging data of 40 patients with non-small cell lung cancer admitted to the First Affiliated Hospital of Hebei North University from January 2017 to December 2018 were retrospectively analyzed. According to the treatment plan, they were divided into observation group (n=20) and control group ( n=20). The control group was treated with conventional NP chemotherapy during 3 consecutive treatment cycles, 21 days in a cycle. The observation group was given intravenous drip of Brucea javanica oil emulsion 30ml and 0.9% sodium chloride injection 250ml in the same perion, 2 times/day, 28 days in a cycle, for 3 consecutive cycles of treatment. TOSHIBA Aquilion One 320-row CT scanner was used for conventional lung CT scan and Target lesion perfusion scan before and after 3 cycles of treatment, and data were recorded, including the changes in lesion size before and after treatment, perfusion parameter values: blood flow (BF), blood volume (BV), mean transit time (MTT), capillary permeability (PS) between groups. Results: After 3 cycles of treatment, the remission rate of the observation group was 60% (12/20), and the remission rate of the control group was 45% (9/20). The remission rate of the observation group was higher than that of the control group (60.0%∶45.0%). The difference was not statistically significant (χ2=0.902, P=0.342); after treatment, the BV and BF levels of the two groups decreased, and the observation group was lower than the control group (P<0.05), the MTT levels of the two groups increased (P<0.05); PS levels in the two groups decreased after treatment, and the observation group was lower than the control group, but the difference was not statistically significant (P>0.05). Conclusion: Brucea javanica oil emulsion is safe and effective in adjuvant treatment of lung cancer. It can inhibit the proliferation of tumor cells, improve the microcirculation of tumor tissues, and improve the immune function of the body. CT perfusion imaging can sensitively reflect the hemodynamic changes of lung cancer lesions, which is the curative effect of lung cancer. The evaluation provides objective functional imaging basis.
2021, Vol. 27 
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