Abstract：Objective: To explore the influence of mannitol application at different times on the prognosis of patients with cerebral hemorrhage and to analyze the related factors. Methods: The clinical data of 80 patients with primary cerebral hemorrhage admitted between January 2017 and December 2020 were retrospectively analyzed. Among them, 40 patients were treated with mannitol 6 hours before admission and were included in group A, and 40 patients who were treated with mannitol 6 hours after admission were included to group B. The prognoses of the two groups of patients were compared before they were divided into a good prognosis group (58 cases) and a poor prognosis group (22 cases). Univariate analysis and multivariate logistic regression were used to analyze the prognostic factors of patients with cerebral hemorrhage. Results: The prognosis of patients in group B was better than that in group A, and the difference was statistically significant (P<0.05). Multivariate logistic regression analysis showed that advanced age, long time from onset to admission, high NIHSS score at admission, high GLU level, and bleeding volume were mostly independent risk factors for poor prognosis in patients with cerebral hemorrhage (P<0.05), while GCS score at admission was high. CT image showed that the midline did not shift, did not break into the ventricle, and the application of mannitol 6 hours after admission was an independent protective factor for the good prognosis of patients with cerebral hemorrhage (P<0.05). Conclusion: Patients with cerebral hemorrhage treated with mannitol 6 hours after admission can get a better prognosis, and age, onset to admission, GCS score, NIHSS score, blood sugar, bleeding volume, midline structure shift, break into the ventricle, and mannitol application timing are related to the prognosis of patients with cerebral hemorrhage. In clinical treatment, timely and effective treatment should be carried out according to the above related factors to improve the prognosis of patients.
刘小菲, 方晨光, 倪军喜. 甘露醇不同时机应用对脑出血患者预后的影响及其相关因素分析[J]. 河北医学, 2021, 27(9): 1490-1495.
LIU Xiaofei , FANG Chenguang , NI Junxi. The Effect of Mannitol Application at Different Times on the Prognosis of Patients with Cerebral Hemorrhage and an Analysis of Related Factors. HeBei Med, 2021, 27(9): 1490-1495.
2021, Vol. 27 
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