Abstract：Objective: To analyze the relationship between the expression of serum insulin-like growth factor 1 (IGF-1) and hepatocyte growth factor (HGF) and prognosis (mortality) of patients with hypofractionated radiotherapy after gliomas surgery. Methods: 53 patients with gliomas who underwent low-dose radiotherapy after operation and received surgery in our hospital from January 2016 to January 2017 were selected. And all patients received low-dose radiotherapy 3~4 weeks after operation, 1.8~2.0 Gy/time, a total of 54~60 Gy. According to the prognosis (death from illness) within 3 years after radiotherapy, the patients were divided into a poor prognosis group and a good prognosis group, investigated the general data of the two groups, tested and compared laboratory indicators, the relationship between serum IGF-1 and HGF expression and prognosis of patients was mainly analyzed. Results: All 53 patients were followed up for 3 years after radiotherapy, 25 were died of illness, and the mortality rate was 47.17%; the serum VEGF, TGF-β, IGF-1 and HGF levels in the poor prognosis patients were higher than the good group (P<0.05); The results of regression analysis showed that VEGF, TGF-β, IGF-1 and HGF were all the risk factors of poor prognosis in patients with hypofractionated radiotherapy after gliomas (OR>1, P<0.05); the ROC curve was drawn,VEGF, TGF-β, IGF-1 and HGF levels alone and in combination predicted the AUC of poor prognosis in patients with low segment radiotherapy after operation were all >0.80, the best prediction value could be obtained when the cut-off value of each index were 221.885pg/ml, 42.205ng/l, 111.080ng/ml and 898.495 μg/l; the correlation analysis showed that there was a positive correlation between serum IGF-I and HGF level in patients with low segment radiotherapy after gliomas (r>0, P<0.05). Conclusion: The overexpression of serum IGF-I and HGF before hypofractionated radiotherapy is associated with poor prognosis after radiotherapy in patients with glioma after operation.
时彩艳, 刘峰, 卢宏全, 黄国定. 血清IGF-I HGF水平与脑胶质瘤术后低分割放疗患者预后的相关性研究[J]. 河北医学, 2021, 27(9): 1477-1481.
SHI Caiyan, LIU Feng, LU Hongquan, et al. Correlation between Serum IGF-I and HGF Levels and Prognosis of Patients with Hypofractionated Radiotherapy after Gliomas Surgery. HeBei Med, 2021, 27(9): 1477-1481.
[1] Hyeon LD,Jeong-Hoon L,Jin JY,et al.Validation of a modified child-turcotte-pugh classification system utilizing insulin-like growth factor-1 for patients with hepatocellular carcinoma in an HBV endemic area[J].PLoS One,2017,12(1):e0170394. [2] Barrdahl M,Canzian F,Gaudet MM,et al.A comprehensive analysis of polymorphic variants in steroid hormone and insulin-like growth factor-1 metabolism and risk of in situ breast cancer:results from the breast and prostate cancer cohort consortium[J].Int Cancer,2018,15(6):1182~1188. [3] Kataoka H,Kawaguchi M,Fukushima T,et al.Hepatocyte growth factor activator inhibitors (HAI‐1 and HAI‐2):Emerging key players in epithelial integrity and cancer[J].Pathol Int,2018,68(3):145~158. [4] Matsumoto K,Umitsu M,De Silva DM,et al.Hepatocyte growth factor/MET in cancer progression and biomarker discovery[J]. Cancer Sci,2017,108(3):296~307. [5] 李小龙,贺俊华,陆婉玲,等.低分割放射治疗分次γ-刀治疗后局部复发脑胶质瘤的疗效观察[J].西部医学,2017,29(6):839~842. [6] 刘云琴,钱立庭, 张红雁,等.58例胶质瘤不同分割剂量调强放疗疗效观察[J].中国肿瘤临床,2010,37(7):395~398. [7] 王宏宇,韦焘,王进昆,等.MCP-1、VEGF在人脑胶质瘤中的表达及其相关性[J].昆明医科大学学报,2020,41(1):26~30. [8] Braak BT,Siezen CL,Lee JS,et al.Insulin-like growth factor 1 receptor activation promotes mammary gland tumor development by increasing glycolysis and promoting biomass production[J].Breast Cancer Res,2017,19(1):14. [9] Oh H,Eliassen AH,Beck AH,et al.Breast cancer risk factors in relation to estrogen receptor,progesterone receptor,insulin-like growth factor-1 receptor,and Ki67 expression in normal breast tissue[J].NP Breast Cancer,2017,3(1):39. [10] Yang XP,Liu SL,Xu JF,et al.Pancreatic stellate cells increase pancreatic cancer cells invasion through the hepatocyte growth factor /c-Met/survivin regulated by P53/P21[J].Exp Cell Res,2017,357(1):79~87. [11] Costa-Silva DR,Maria BO,Borges RS,et al.Insulin-like growth factor 1 gene polymorphism in women with breast cancer[J].Med Oncol,2017,34(4):59.
2021, Vol. 27 
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