Abstract：Objective: To analyze the correlation between serum 25-hydroxyvitamin D[25(OH)D]and homocysteine(Hcy) levels and left ventricular function in patients with hypothyroidism. Methods: From January 2017 to January 2021, 121 patients with hypothyroidism were selected as the observation group. Meanwhile, 80 healthy individuals were selected as the control group. Serum 25(OH)D and Hcy levels, and left ventricular function indicators [left ventricular end diastolic diameter (LVEDD), left ventricular end systolic diameter (LVESD), left ventricular posterior wall thickness (LVPW), interventricular septal thickness (IVS), left ventricular ejection fraction (LVEF)] were tested. Pearson correlation analysis was performed to analyze the correlation of serum 25(OH)D and Hcy levels with LVEDD, LVESD, LVPW, IVS, and LVEF. Results: Compared with the control group, the observation group had lower serum 25(OH)D level, higher Hcy level, larger IVS and LVPW, and lower LVEF (P<0.05). There were no significant differences in LVEDD and LVESD between the two groups (P>0.05). Pearson correlation analysis showed that serum 25(OH)D level was negatively correlated with LVPW and IVS, and was positively correlated with LVEF (P<0.05). Serum Hcy level was positively correlated with LVPW and IVS, and was negatively correlated with LVEF (P<0.05). Conclusion: In patients with hypothyroidism, 25(OH)D level decreases and Hcy level increases, which aggravates myocardial damage and impaired left ventricular function.
党倩, 康菊鸽. 甲状腺功能减退患者血清25羟维生素D及Hcy水平与左心室功能的关系[J]. 河北医学, 2021, 27(9): 1440-1443.
DANG Qian, KANG Juge. An Analysis of the Correlation Between Serum 25-Hydroxyvitamin D and Hcy Levels and Left Ventricular Function in Patients with Hypothyroidism. HeBei Med, 2021, 27(9): 1440-1443.
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2021, Vol. 27 
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