Abstract：Objective: To investigate the efficacy of alanyl-glutamine in the treatment of patients with sepsis in ICU, and its influence on serum C-reactive protein (CRP), endotoxin (ETX) and heparin-binding protein (HBP) levels. Methods: From February 2019 to February 2021, 152 patients with sepsis in ICU of the hospital were selected and divided into observation group and control group, 76 cases in each group, with random number table for simple random grouping. The control group received conventional treatment, and the observation group was treated with alanyl-glutamine on the basis of conventional treatment. Clinical effects, mechanical ventilation time, hospitalization time, acute physiology and chronic health evaluation II (APACHEII) scores, serum CRP, ETX and HBP levels, liver function indicators [lactate (LAC), aspartate aminotransferase (AST), alanine aminotransferase (ALT)], nutritional indicators [albumin (ALB), hemoglobin (Hb), transferrin (TF)], and immune indicators [immunoglobulins (IgA, IgG, IgM) and complements (C3, C4)] were compared between the two groups. Results: The effective rate of treatment in the observation group was higher than that in the control group (84.00% vs. 66.77%) (P<0.05). The mechanical ventilation time and hospital stay of the observation group were shorter than those of the control group (P<0.05). After treatment, the levels of serum CRP, ETX, HBP, LAC, AST and ALT were reduced, while the levels of ALB, Hb, TF, IgA, IgG, IgM, C3 and C4 were increased (P<0.05). Meanwhile, the APACHEⅡ score and levels of serum CRP, ETX, HBP, LAC, AST and ALT in the observation group were lower than those in the control group, while the levels of ALB, Hb, TF, IgA, IgG, IgM, C3 and C4 were higher than those in the control group (P<0.05). Conclusion: Alanyl-glutamine is effective in the treatment of patients with sepsis in ICU. It can lower serum CRP, ETX and HBP levels, improve nutritional status and liver function, and improve immune function.
陈宇晟, 刘小敏. 丙氨酰谷氨酰胺治疗ICU脓毒症患者疗效及对血清CRP ETX和HBP水平的影响[J]. 河北医学, 2021, 27(8): 1285-1290.
CHEN Yusheng, LIU Xiaomin. Efficacy of Alanyl-Glutamine in the Treatment of Patients with Sepsis in ICU and Its Influence on Serum CRP, ETX and HBP Levels. HeBei Med, 2021, 27(8): 1285-1290.
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2021, Vol. 27 
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