Abstract：Objective: To detect the embryo chromosomal karyotype abnormality of patients with spontaneous abortion after in vitro fertilization/intracytoplasmic sperm injection-embryo transfer (IVF/ICSI-ET), and to explore the relationship between body mass index (BMI) and embryo chromosomal karyotype abnormality of patients with spontaneous abortion after IVF/ICSI-ET. Methods: 280 cases of patients with spontaneous abortion after IVF/ICSI-ET from January 2018 to July 2020 in department of obstetrics and gynecology, Tianmen first people's hospital were analyzed retrospectively, including 96 cases of embryonic chromosome normal karyotype patients (normal karyotype group) and 184 cases of embryonic chromosome abnormal karyotype patients (abnormal karyotype group). General data were analyzed; embryo chromosomal karyotype abnormality of patients with spontaneous abortion after IVF/ICSI-ET was analyzed; and the relationships between BMI, abortion age, abortion times and embryo chromosomal karyotype abnormality of patients with spontaneous abortion after IVF/ICSI-ET was analyzed; Logistic regression analysis of the factors influencing the embryonic chromosome abnormal karyotype in patients with spontaneous abortion after IVF/ICSI-ET. Results: There was no significant difference between the two groups in infertility duration, causes of infertility, type of infertility, mode of pregnancy aid, dosage of gonadotropins(GN), days of GN use, basic follicle-stimulating hormone(FSH), number of oocytes obtained, thickness of endometrium on the day of transplantation, number of embryos transferred and number of high-quality embryos transferred (P>0.05); the proportions of normal karyotype group and abnormal karyotype group were 34.29% and 65.71% respectively, and aneuploidy was the main karyotype in abnormal karyotype group (41.07%); the percentage of abnormal karyotypes in patients with spontaneous abortion after IVF/ICSI-ET whose BMI < 21.4 kg/m2 or > 24.2 kg/m2 was significantly higher than that in patients whose BMI of 21.4 kg/m2~24.2 kg/m2 (P<0.05); the percentage of abnormal karyotype in patients with spontaneous abortion after IVF/ICSI-ET whose abortion age ≥ 36 years old was significantly higher than that in patients whose abortion age < 36 years old (P<0.05); the percentage of abnormal karyotype in patients with spontaneous abortion after IVF/ICSI-ET whose abortion times > 2 times was significantly higher than that in patients whose abortion times ≤ 2 times (P<0.05); BMI is an independent risk factor that affects the abnormal karyotype of embryos in spontaneous abortion patients after IVF/ICSI-ET (P<0.05). Conclusions: After IVF/ICSI-ET operation, most of the spontaneous abortion patients are embryo chromosomal karyotype abnormality, and the BMI of the patients was related to the embryo chromosomal karyotype abnormality.
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2021, Vol. 27 
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