恩替卡韦联合多烯磷脂酰胆碱对慢性乙型肝炎合并非酒精性脂肪肝患者平均血小板体积血尿酸及TGFβ1的影响

doi:10.3969/j.issn.1006-6233.2021.07.008

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摘要 目的: 分析恩替卡韦联合多烯磷脂酰胆碱治疗对慢性乙型肝炎合并非酒精性脂肪肝患者平均血小板体积、血尿酸及TGFβ1的影响。方法: 回顾性分析本院2017年1月至2019年8月收治的CHB合并NAFLD患者146例,根据治疗方式不同分为常规组(常规+恩替卡韦治疗)68例与联合组(恩替卡韦+多烯磷脂酰胆碱治疗)78例。对比两组患者治疗后临床效果、平均血小板体积(Mean platelet volume,MPV)、血尿酸(Serum uric acid,BUA)、转化生长因子β1(Transforming growth factor β1,TGFβ1)、肝功能以及不良反应情况。结果: 治疗后常规组临床总有效率为75.00%,明显低于联合组(88.46%)(P<0.05);治疗后MPV、BUA、TGFβ1水平均为下降趋势,联合组MPV、BUA、TGFβ1治疗后水平降低差值明显大于常规组(P<0.05);治疗后,两组患者肝功能情况均有所改善,治疗后联合组AST、TBIL、ALB水平治疗前后差值明显大于常规组(P<0.05);在治疗后常规组患者不良反应总发生率为1.47%,联合组为2.56%,两组间比较无差异(P>0.05)。结论: 恩替卡韦联合多烯磷脂酰胆碱治疗可降低CHB合并NFALD患者MPV、BUA、TGFβ1水平,延缓病情进展,改善肝功能,提高治疗效果。

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	李潇
	时洁
	张立伟

关键词 ：恩替卡韦, 多烯磷脂酰胆碱, 慢性乙型肝炎合并非酒精性脂肪肝, 平均血小板体积, 血尿酸, TGFβ1

Abstract：Objective: To analyze the effect of entecavir combined with polyene phosphatidylcholine treatment on average platelet volume, blood uric acid and TGFβ1 in patients with chronic hepatitis B combined with non-alcoholic fatty liver disease. Methods: The 146 patients with CHB combined with NAFLD admitted to this hospital from January 2017 to August 2019 were retrospectively analyzed. According to different treatment methods, patients were divided into the conventional group (conventional + entecavir treatment), 68 cases, and the combined group (entecavir + polyene phosphatidylcholine treatment), 78 cases. The clinical effects, mean platelet volume (MPV), serum uric acid (BUA), transforming growth factor β1 (TGFβ1), liver function and adverse reactions after treatment were compared between the two groups. Results: After treatment, the total clinical effective rate of the conventional group was 75.00%, which was significantly lower than that of the combination group (88.46%) (P<0.05). After treatment, the levels of MPV, BUA, and TGFβ1 all declined, and the declining in the combined group after treatment was significantly greater than that in the conventional group(P<0.05). After treatment, the liver function of the two groups improved. After treatment, the differences in AST, TBIL, and ALB levels in the combined group before and after treatment were significantly greater than those in the conventional group(P<0.05). After treatment, the total incidence of adverse reactions was 1.47% in the conventional group and 2.56% in the combination group. There was no difference between the two groups (P>0.05). Conclusion: Entecavir combined with polyene phosphatidylcholine therapy can reduce the levels of MPV, BUA and TGFβ1 in patients with CHB and NFALD, delay the progression of the disease, improve liver function, and improve the therapeutic effect.

Key words： Entecavir Polyene phosphatidylcholine Chronic hepatitis B with non-alcoholic fatty liver disease Mean platelet volume Blood uric acid TGFβ1

基金资助:湖北省自然科学基金,(编号:2017CFB355)

通讯作者: 时洁

引用本文:

李潇, 时洁, 张立伟. 恩替卡韦联合多烯磷脂酰胆碱对慢性乙型肝炎合并非酒精性脂肪肝患者平均血小板体积血尿酸及TGFβ1的影响[J]. 河北医学, 2021, 27(7): 1094-1098.
LI Xiao, SHI Jie, et al. Effect of Entecavir Combined with Polyene Phosphatidylcholine on Average Platelet Volume Blood Uric Acid and TGFβ1 in Patients with Chronic Hepatitis B Combined with NAFLD. HeBei Med, 2021, 27(7): 1094-1098.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2021.07.008 或 http://www.hbyxzzs.cn/CN/Y2021/V27/I7/1094

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