Abstract：Objective: To explore the efficacy of levonorgestrel intrauterine sustained-release system(LNG-IUS)in the treatment of endometrial hyperplasia. Methods: A total of 260 patients with endometrial hyperplasia admitted in our hospital from April 2019 to April 2020 were selected. The selected patients met the inclusion criteria and were randomly divided into two groups, each with 130 cases. During treatment, medroxyprogesterone acetate was administered to the control group, and LNG-IUS was administered to the observation group. The curative effect was compared through 3 menstrual periods. Results: Before treatment, there was no difference in endometrial thickness and hemoglobin level between the two groups(P>0.05);After treatment, the endometrial thickness and hemoglobin level of the observation group were better than those of the control group(P<0.05).Before treatment, there was no difference in the scores of PBAC, menstrual volume and progesterone receptor between the two groups(P>0.05); After treatment, PBAC, progesterone receptor score and menstrual volume of the observation group were better than those of the control group(P<0.05).The levels of E2(estradiol),P(progesterone),LH(luteinizing hormone) and FSH(serum follicle stimulating hormone)in the observation group were significantly different before and after treatment(P<0.05),with statistical significance; The levels of E2(estradiol),P(progesterone),LH(luteinizing hormone)and FSH(serum follicle stimulating hormone)in the control group were not significantly different before and after treatment(P>0.05).During the treatment period, the LNG-IUS of 3 patients in the observation group fell off due to excessive menstruation,26 cases had abnormal vaginal bleeding,1 case was taken out midway, and 3 cases were closed; In the control group,4 patients had poor symptom control and 6 patients were diagnosed with pregnancy; During the treatment, there were no coagulation, renal and liver dysfunction in both groups. Conclusion: The choice of LNG-IUS for the treatment of endometrial hyperplasia has a definite curative effect and can effectively regulate the level of progesterone, thereby implementing effective treatment for endometrial hyperplasia, which is worthy of promotion.
崔冠群. 左炔诺孕酮宫内缓释系统治疗子宫内膜增生的疗效[J]. 河北医学, 2021, 27(6): 1045-1048.
CUI Guanqun. Efficacy of Levonorgestrel Intrauterine Sustained-Release System in the Treatment of Endometrial Hyperplasia. HeBei Med, 2021, 27(6): 1045-1048.
2021, Vol. 27 
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