羊膜移植与自体结膜移植对翼状胬肉手术患者视觉质量角膜屈光及泪膜功能的影响

doi:10.3969/j.issn.1006-6233.2021.06.010

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摘要 目的: 探究羊膜移植与自体结膜移植对翼状胬肉手术患者视觉质量、角膜屈光及泪膜功能的影响。方法: 前瞻性纳入2018年6月至2019年11月医院收治的220例翼状胬肉手术患者为对象,随机数字表法简单随机分为对照组、实验组各110例。对照组翼状胬肉手术后采用羊膜移植治疗,实验组则应用自体结膜移植治疗。比较两组治疗效果,观察治疗前后两组视觉质量、角膜屈光及泪膜功能,同时对比两组并发症发生率。结果: 两组总有效率、复发率比较差异无统计学意义(P>0.05)。与同组治疗前比较,治疗后一个月、3个月两组MTF、SR、SIT、BUT明显升高,且实验组明显高于对照组(P<0.05),而两组TF-OSI、角膜屈光度明显降低,且实验组明显低于对照组(P<0.05)。实验组复发率、并发症发生率略低于对照组(P>0.05)。结论: 自体结膜移植治疗翼状胬肉手术患者的临床效果与与羊膜移植相当,但前者更利于患者视觉质量、角膜屈光及泪膜功能的改善,且并发症发生风险相对低。

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	黄丽娟
	林雪松

关键词 ：翼状胬肉, 羊膜移植, 自体结膜移植, 视觉质量, 角膜屈光, 泪膜功能

Abstract：Objective: To explore the effects of amniotic membrane transplantation and conjunctival autograft transplantation on visual quality, corneal refractive power and tear film function of patients undergoing pterygium surgery. Methods: A prospective study was conducted among 220 patients undergoing pterygium surgery at the hospital between June 2018 and November 2019. They were randomly divided into control group and experimental group by random number table method, 110 cases in each group. The control group was treated with amniotic membrane transplantation after pterygium surgery, and the experimental group was treated with conjunctival autograft transplantation. Therapeutic effects of the 2 groups were compared. Visual quality, corneal refractive power and tear film function of the 2 groups were observed before and after treatment. Meanwhile, the incidence of complications was compared between the 2 groups. Results: There were no significant differences in the total response rate and recurrence rate between the 2 groups (P>0.05). Compared with the same group before treatment, MTF, SR, SIT and BUT of both groups were significantly increased. Besides, the above indexes of experimental group were significantly higher than those of the control group (P<0.05). However, TF-OSI and corneal refractive power were significantly reduced, which were significantly lower in the experimental group than the control group (P<0.05). The recurrence rate and the incidence of complications in experimental group were slightly lower than those in the control group (P>0.05). Conclusion: Clinical effects of conjunctival autograft transplantation and amniotic membrane transplantation are similar in patients undergoing pterygium surgery. However, the former is more conducive to the improvement of visual quality, corneal refractive power and tear film function. Besides, the risk of complications is lower.

Key words： Pterygium Amniotic membrane transplantation Conjunctival autograft transplantation Visual quality Corneal refractive power Tear film function

基金资助:福建省自然科学基金项目编号,(编号:2016PJ010659)

引用本文:

黄丽娟, 林雪松. 羊膜移植与自体结膜移植对翼状胬肉手术患者视觉质量角膜屈光及泪膜功能的影响[J]. 河北医学, 2021, 27(6): 924-929.
HUANG Lijuan, LIN Xuesong. Effects of Amniotic Membrane Transplantation and Conjunctival Autograft Transplantation on Visual Quality Corneal Refractive Power and Tear Film Function of Patients Undergoing Pterygium Surgery. HeBei Med, 2021, 27(6): 924-929.

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http://www.hbyxzzs.cn/CN/10.3969/j.issn.1006-6233.2021.06.010 或 http://www.hbyxzzs.cn/CN/Y2021/V27/I6/924